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The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Mariëlle Alders
  • Matt Hodges
  • Anna-Katerina Hadjantonakis
  • Jan Postmus
  • Inge van Wijk
  • Jet Bliek
  • Maurice de Meulemeester
  • Andries Westerveld
  • François Guillemot
  • Cees Oudejans
  • Peter Little
  • Marcel Mannens
<mark>Journal publication date</mark>06/1997
<mark>Journal</mark>Human Molecular Genetics
Issue number6
Number of pages9
Pages (from-to)859-867
Publication StatusPublished
<mark>Original language</mark>English


Here we describe the cloning of the human Achaete Scute Homologue 2 (HASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2), a homologue of the DrosophilaAchaete and Scute genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man. HASH2 is expressed in the extravillus trophoblasts of the developing placenta only. The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH2 is also imprinted in man.