We create a new family of Banach spaces, the James-Schreier spaces, by amalgamating two important classical Banach spaces: James' quasi-reflexive Banach space on the one hand and Schreier's Banach space giving a counterexample to the Banach-Saks property on the other. We then investigate the properties of these James-Schreier spaces, paying particular attention to how key properties of their `ancestors' (that is, the James space and the Schreier space) are expressed in them. Our main results include that each James-Schreier space is c_0-saturated and that no James-Schreier space embeds in a Banach space with an unconditional basis.