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Glycopolymer functionalization of engineered spider silk protein-based materials for improved cell adhesion

Research output: Contribution to journalJournal article

Published
  • John G. Hardy
  • Andre Pfaff
  • Aldo Leal-Egana
  • Axel H. E. Mueller
  • Thomas R. Scheibel
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<mark>Journal publication date</mark>07/2014
<mark>Journal</mark>Macromolecular Bioscience
Issue number7
Volume14
Number of pages7
Pages (from-to)936-942
StatePublished
Early online date2/04/14
Original languageEnglish

Abstract

Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.