Glycopolymer functionalization of engineered spider silk protein-based materials for improved cell adhesion
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
| <mark>Journal publication date</mark> | 07/2014 |
|---|---|
| <mark>Journal</mark> | Macromolecular Bioscience |
| Issue number | 7 |
| Volume | 14 |
| Number of pages | 7 |
| Pages (from-to) | 936-942 |
| Publication Status | Published |
| Early online date | 2/04/14 |
| <mark>Original language</mark> | English |
Abstract
Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.