Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Glycopolymer functionalization of engineered spider silk protein-based materials for improved cell adhesion
AU - Hardy, John G.
AU - Pfaff, Andre
AU - Leal-Egana, Aldo
AU - Mueller, Axel H. E.
AU - Scheibel, Thomas R.
PY - 2014/7
Y1 - 2014/7
N2 - Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.
AB - Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.
KW - POLYMERS
KW - RGD
KW - BIOMATERIAL
KW - SURFACES
KW - COATINGS
KW - collagen type 1 adhesin
KW - Laminin
KW - Biomaterials
KW - Chemistry(all)
U2 - 10.1002/mabi.201400020
DO - 10.1002/mabi.201400020
M3 - Journal article
VL - 14
SP - 936
EP - 942
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
SN - 1616-5187
IS - 7
ER -