Research output: Contribution to Journal/Magazine › Journal article › peer-review
<mark>Journal publication date</mark> | 15/03/2013 |
---|---|
<mark>Journal</mark> | Organic Process Research and Development |
Issue number | 3 |
Volume | 17 |
Number of pages | 9 |
Pages (from-to) | 397-405 |
Publication Status | Published |
<mark>Original language</mark> | English |
The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.