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A robust first-pass protocol for the Heck-Mizoroki reaction

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<mark>Journal publication date</mark>15/03/2013
<mark>Journal</mark>Organic Process Research and Development
Issue number3
Volume17
Number of pages9
Pages (from-to)397-405
Publication StatusPublished
<mark>Original language</mark>English

Abstract

The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.