Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - A robust first-pass protocol for the Heck-Mizoroki reaction
AU - Murray, Paul M.
AU - Bower, John F.
AU - Cox, David K.
AU - Galbraith, Ewan K.
AU - Parker, Jeremy S.
AU - Sweeney, Joseph B.
PY - 2013/3/15
Y1 - 2013/3/15
N2 - The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.
AB - The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.
U2 - 10.1021/op300364p
DO - 10.1021/op300364p
M3 - Journal article
AN - SCOPUS:84875154438
VL - 17
SP - 397
EP - 405
JO - Organic Process Research and Development
JF - Organic Process Research and Development
SN - 1083-6160
IS - 3
ER -