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α-Synuclein and the pathogenesis of Parkinson’s disease.

Research output: Contribution to journalJournal article

Published

Journal publication date2004
JournalProtein and Peptide Letters
Journal number3
Volume11
Number of pages9
Pages229-237
Original languageEnglish

Abstract

Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.