Research output: Contribution to journal › Journal article › peer-review
α-Synuclein and the pathogenesis of Parkinson’s disease. / Martin, Frank; Allsop, David; Williamson, Sally J. M.; Paleologou, Katerina E.; El-Agnaf, Omar M. A.
In: Protein and Peptide Letters, Vol. 11, No. 3, 2004, p. 229-237.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - α-Synuclein and the pathogenesis of Parkinson’s disease.
AU - Martin, Frank
AU - Allsop, David
AU - Williamson, Sally J. M.
AU - Paleologou, Katerina E.
AU - El-Agnaf, Omar M. A.
PY - 2004
Y1 - 2004
N2 - Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.
AB - Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.
M3 - Journal article
VL - 11
SP - 229
EP - 237
JO - Protein and Peptide Letters
JF - Protein and Peptide Letters
SN - 0929-8665
IS - 3
ER -