α-Synuclein and the pathogenesis of Parkinson’s disease.

Links

http://www.bentham.org/ppl/contabs/ppl11-3.htm##link3

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

α-Synuclein and the pathogenesis of Parkinson’s disease. / Martin, Frank ; Allsop, David; Williamson, Sally J. M. et al.
In: Protein and Peptide Letters, Vol. 11, No. 3, 2004, p. 229-237.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Martin, F , Allsop, D, Williamson, SJM, Paleologou, KE & El-Agnaf, OMA 2004, 'α-Synuclein and the pathogenesis of Parkinson’s disease.', Protein and Peptide Letters, vol. 11, no. 3, pp. 229-237. <http://www.bentham.org/ppl/contabs/ppl11-3.htm##link3>

APA

Martin, F., Allsop, D., Williamson, S. J. M., Paleologou, K. E., & El-Agnaf, O. M. A. (2004). α-Synuclein and the pathogenesis of Parkinson’s disease. Protein and Peptide Letters, 11(3), 229-237. http://www.bentham.org/ppl/contabs/ppl11-3.htm##link3

Vancouver

Martin F , Allsop D, Williamson SJM, Paleologou KE, El-Agnaf OMA. α-Synuclein and the pathogenesis of Parkinson’s disease. Protein and Peptide Letters. 2004;11(3):229-237.

Author

Martin, Frank ; Allsop, David ; Williamson, Sally J. M. et al. / α-Synuclein and the pathogenesis of Parkinson’s disease. In: Protein and Peptide Letters. 2004 ; Vol. 11, No. 3. pp. 229-237.

Bibtex

@article{799090ea7a9d48f08a5b98b65ed8e91a,

title = "α-Synuclein and the pathogenesis of Parkinson{\textquoteright}s disease.",

abstract = "Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson{\textquoteright}s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.",

author = "Frank Martin and David Allsop and Williamson, {Sally J. M.} and Paleologou, {Katerina E.} and El-Agnaf, {Omar M. A.}",

year = "2004",

language = "English",

volume = "11",

pages = "229--237",

journal = "Protein and Peptide Letters",

issn = "0929-8665",

publisher = "Bentham Science Publishers B.V.",

number = "3",

}

RIS

TY - JOUR

T1 - α-Synuclein and the pathogenesis of Parkinson’s disease.

AU - Martin, Frank

AU - Allsop, David

AU - Williamson, Sally J. M.

AU - Paleologou, Katerina E.

AU - El-Agnaf, Omar M. A.

PY - 2004

Y1 - 2004

N2 - Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

AB - Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

M3 - Journal article

VL - 11

SP - 229

EP - 237

JO - Protein and Peptide Letters

JF - Protein and Peptide Letters

SN - 0929-8665

IS - 3

ER -

Research

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