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α-Synuclein and the pathogenesis of Parkinson’s disease.

Research output: Contribution to journalJournal article


<mark>Journal publication date</mark>2004
<mark>Journal</mark>Protein and Peptide Letters
Issue number3
Number of pages9
Pages (from-to)229-237
<mark>Original language</mark>English


Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.