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α-Synuclein and the pathogenesis of Parkinson’s disease.

Research output: Contribution to journalJournal article


Journal publication date2004
JournalProtein and Peptide Letters
Number of pages9
Original languageEnglish


Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson’s disease (PD) patients. Intracellular aggregation of a-synuclein (a-syn) appears to play a key role in the generation of LBs andLNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.