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Research output: Contribution to Journal/Magazine › Journal article
Research output: Contribution to Journal/Magazine › Journal article
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TY - JOUR
T1 - Beyond sensing DNA
T2 - A role for cGAS in the detection of extracellular cyclic di-nucleotides
AU - Unterholzner, Leonie
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Cyclic GMP-AMP synthase (cGAS) is best known as an innate immune receptor that detects pathogen DNA in the cytosol. In this issue of EMBO Reports, Kaufmann and colleagues report that cGAS has an additional role in innate immunity: It can also bind cyclic di-nucleotides (CDNs), signalling molecules produced by bacteria. The authors show that when extracellular CDNs are taken up by endocytosis, they bind to cGAS, causing it to form a complex with the CDN receptor STING (STimulator of INterferon Genes), thereby enhancing its activation. As cGAS is dispensable for the detection of intracellular CDNs, this work exemplifies how the localisation of pathogen-associated molecular patterns (PAMPs) influences innate immune signalling.
AB - Cyclic GMP-AMP synthase (cGAS) is best known as an innate immune receptor that detects pathogen DNA in the cytosol. In this issue of EMBO Reports, Kaufmann and colleagues report that cGAS has an additional role in innate immunity: It can also bind cyclic di-nucleotides (CDNs), signalling molecules produced by bacteria. The authors show that when extracellular CDNs are taken up by endocytosis, they bind to cGAS, causing it to form a complex with the CDN receptor STING (STimulator of INterferon Genes), thereby enhancing its activation. As cGAS is dispensable for the detection of intracellular CDNs, this work exemplifies how the localisation of pathogen-associated molecular patterns (PAMPs) influences innate immune signalling.
U2 - 10.15252/embr.201947970
DO - 10.15252/embr.201947970
M3 - Journal article
VL - 20
JO - EMBO Reports
JF - EMBO Reports
SN - 1469-221X
IS - 4
M1 - e47970
ER -