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Beyond sensing DNA: A role for cGAS in the detection of extracellular cyclic di-nucleotides

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Beyond sensing DNA: A role for cGAS in the detection of extracellular cyclic di-nucleotides. / Unterholzner, Leonie.
In: EMBO Reports, Vol. 20, No. 4, e47970, 01.04.2019.

Research output: Contribution to Journal/Magazine › Journal article

Harvard

Unterholzner, L 2019, 'Beyond sensing DNA: A role for cGAS in the detection of extracellular cyclic di-nucleotides', EMBO Reports, vol. 20, no. 4, e47970. https://doi.org/10.15252/embr.201947970

APA

Unterholzner, L. (2019). Beyond sensing DNA: A role for cGAS in the detection of extracellular cyclic di-nucleotides. EMBO Reports, 20(4), Article e47970. https://doi.org/10.15252/embr.201947970

Vancouver

Unterholzner L. Beyond sensing DNA: A role for cGAS in the detection of extracellular cyclic di-nucleotides. EMBO Reports. 2019 Apr 1;20(4):e47970. Epub 2019 Mar 19. doi: 10.15252/embr.201947970

Author

Unterholzner, Leonie. / Beyond sensing DNA : A role for cGAS in the detection of extracellular cyclic di-nucleotides. In: EMBO Reports. 2019 ; Vol. 20, No. 4.

Bibtex

@article{3eb39ecf2a0b4be7af3c3bea4ffdebac,
title = "Beyond sensing DNA: A role for cGAS in the detection of extracellular cyclic di-nucleotides",
abstract = "Cyclic GMP-AMP synthase (cGAS) is best known as an innate immune receptor that detects pathogen DNA in the cytosol. In this issue of EMBO Reports, Kaufmann and colleagues report that cGAS has an additional role in innate immunity: It can also bind cyclic di-nucleotides (CDNs), signalling molecules produced by bacteria. The authors show that when extracellular CDNs are taken up by endocytosis, they bind to cGAS, causing it to form a complex with the CDN receptor STING (STimulator of INterferon Genes), thereby enhancing its activation. As cGAS is dispensable for the detection of intracellular CDNs, this work exemplifies how the localisation of pathogen-associated molecular patterns (PAMPs) influences innate immune signalling. ",
author = "Leonie Unterholzner",
year = "2019",
month = apr,
day = "1",
doi = "10.15252/embr.201947970",
language = "English",
volume = "20",
journal = "EMBO Reports",
issn = "1469-221X",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Beyond sensing DNA

T2 - A role for cGAS in the detection of extracellular cyclic di-nucleotides

AU - Unterholzner, Leonie

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Cyclic GMP-AMP synthase (cGAS) is best known as an innate immune receptor that detects pathogen DNA in the cytosol. In this issue of EMBO Reports, Kaufmann and colleagues report that cGAS has an additional role in innate immunity: It can also bind cyclic di-nucleotides (CDNs), signalling molecules produced by bacteria. The authors show that when extracellular CDNs are taken up by endocytosis, they bind to cGAS, causing it to form a complex with the CDN receptor STING (STimulator of INterferon Genes), thereby enhancing its activation. As cGAS is dispensable for the detection of intracellular CDNs, this work exemplifies how the localisation of pathogen-associated molecular patterns (PAMPs) influences innate immune signalling.

AB - Cyclic GMP-AMP synthase (cGAS) is best known as an innate immune receptor that detects pathogen DNA in the cytosol. In this issue of EMBO Reports, Kaufmann and colleagues report that cGAS has an additional role in innate immunity: It can also bind cyclic di-nucleotides (CDNs), signalling molecules produced by bacteria. The authors show that when extracellular CDNs are taken up by endocytosis, they bind to cGAS, causing it to form a complex with the CDN receptor STING (STimulator of INterferon Genes), thereby enhancing its activation. As cGAS is dispensable for the detection of intracellular CDNs, this work exemplifies how the localisation of pathogen-associated molecular patterns (PAMPs) influences innate immune signalling.

U2 - 10.15252/embr.201947970

DO - 10.15252/embr.201947970

M3 - Journal article

VL - 20

JO - EMBO Reports

JF - EMBO Reports

SN - 1469-221X

IS - 4

M1 - e47970

ER -