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  • Douglas_Sobczyk_Lapa_rewizja_2017_02_08

    Rights statement: This is an author-created, un-copyedited version of an article accepted for publication/published in Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at doi:10.1088/1748-605X/aa6200

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Ca:Mg:Zn:CO3 and Ca:Mg:CO3-tri- and bi-elemental carbonate microparticles for novel injectable self-gelling hydrogel-microparticle composites for tissue regeneration

Research output: Contribution to journalJournal article

Published
  • Katarzyna Sobczyk
  • Agata Łapa
  • Katarzyna Włodarczyk
  • Gilles Brackman
  • Irina Vidiasheva
  • Katarzyna Reczyńska
  • Krzysztof Pietryga
  • David Schaubroeck
  • Vitaliy Bliznuk
  • Pascal Van Der Voort
  • Heidi Declercq
  • Jan Van den Bulcke
  • Sangram Keshari Samal
  • Dmitry Khalenkow
  • Bogdan Parakhonskiy
  • Joris Van Acker
  • Tom Coenye
  • Małgorzata Lewandowska-Szumieł
  • Elżbieta Pamuła
  • Andre Skirtach
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<mark>Journal publication date</mark>24/03/2017
<mark>Journal</mark>Biomedical Materials
Issue number2
Volume12
Publication statusPublished
Early online date22/03/17
Original languageEnglish

Abstract

Injectable composites for tissue regeneration can be developed by dispersion of inorganic microparticles and cells in a hydrogel phase. In this study, multifunctional carbonate microparticles containing different amounts of calcium, magnesium and zinc were mixed with solutions of gellan gum (GG), an anionic polysaccharide, to form injectable hydrogel-microparticle composites, containing Zn, Ca and Mg. Zn and Ca were incorporated into microparticle preparations to a greater extent than Mg. Microparticle groups were heterogeneous and contained microparticles of differing shape and elemental composition. Zn-rich microparticles were 'star shaped' and appeared to consist of small crystallites, while Zn-poor, Ca- and Mg-rich microparticles were irregular in shape and appeared to contain lager crystallites. Zn-free microparticle groups exhibited the best cytocompatibility and, unexpectedly, Zn-free composites showed the highest antibacterial activity towards methicilin-resistant Staphylococcus aureus. Composites containing Zn-free microparticles were cytocompatible and therefore appear most suitable for applications as an injectable biomaterial. This study proves the principle of creating bi- and tri-elemental microparticles to induce the gelation of GG to create injectable hydrogel-microparticle composites.

Bibliographic note

This is an author-created, un-copyedited version of an article accepted for publication/published in Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at doi:10.1088/1748-605X/aa6200