Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein
AU - Allsop, D
AU - Ikeda, S
AU - Bruce, M
AU - Glenner, G G
PY - 1988/10/5
Y1 - 1988/10/5
N2 - In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27-30), but not with antibodies to the amyloid beta-protein of Alzheimer's disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.
AB - In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27-30), but not with antibodies to the amyloid beta-protein of Alzheimer's disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.
KW - Amyloid
KW - Animals
KW - Brain
KW - Cerebrovascular Circulation
KW - Cricetinae
KW - Immunohistochemistry
KW - Prions
KW - Scrapie
KW - Sheep
U2 - 10.1016/0304-3940(88)90067-5
DO - 10.1016/0304-3940(88)90067-5
M3 - Journal article
C2 - 3185993
VL - 92
SP - 234
EP - 239
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -