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Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein

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Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein. / Allsop, D; Ikeda, S; Bruce, M et al.
In: Neuroscience Letters, Vol. 92, No. 2, 05.10.1988, p. 234-239.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Allsop, D, Ikeda, S, Bruce, M & Glenner, GG 1988, 'Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein', Neuroscience Letters, vol. 92, no. 2, pp. 234-239. https://doi.org/10.1016/0304-3940(88)90067-5

APA

Allsop, D., Ikeda, S., Bruce, M., & Glenner, G. G. (1988). Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein. Neuroscience Letters, 92(2), 234-239. https://doi.org/10.1016/0304-3940(88)90067-5

Vancouver

Allsop D, Ikeda S, Bruce M, Glenner GG. Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein. Neuroscience Letters. 1988 Oct 5;92(2):234-239. doi: 10.1016/0304-3940(88)90067-5

Author

Allsop, D ; Ikeda, S ; Bruce, M et al. / Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein. In: Neuroscience Letters. 1988 ; Vol. 92, No. 2. pp. 234-239.

Bibtex

@article{6e19ccaabe984e78a63b0d434b3599b9,
title = "Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein",
abstract = "In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27-30), but not with antibodies to the amyloid beta-protein of Alzheimer's disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.",
keywords = "Amyloid, Animals, Brain, Cerebrovascular Circulation, Cricetinae, Immunohistochemistry, Prions, Scrapie, Sheep",
author = "D Allsop and S Ikeda and M Bruce and Glenner, {G G}",
year = "1988",
month = oct,
day = "5",
doi = "10.1016/0304-3940(88)90067-5",
language = "English",
volume = "92",
pages = "234--239",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "ELSEVIER IRELAND LTD",
number = "2",

}

RIS

TY - JOUR

T1 - Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein

AU - Allsop, D

AU - Ikeda, S

AU - Bruce, M

AU - Glenner, G G

PY - 1988/10/5

Y1 - 1988/10/5

N2 - In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27-30), but not with antibodies to the amyloid beta-protein of Alzheimer's disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.

AB - In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27-30), but not with antibodies to the amyloid beta-protein of Alzheimer's disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.

KW - Amyloid

KW - Animals

KW - Brain

KW - Cerebrovascular Circulation

KW - Cricetinae

KW - Immunohistochemistry

KW - Prions

KW - Scrapie

KW - Sheep

U2 - 10.1016/0304-3940(88)90067-5

DO - 10.1016/0304-3940(88)90067-5

M3 - Journal article

C2 - 3185993

VL - 92

SP - 234

EP - 239

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -