TY - JOUR

T1 - Combinatorial exploration of polymeric transport agents for targeted delivery of bioactives to human tissues.

AU - Kolosov, Oleg

AU - Liu, Mingjun

AU - Nguyen, Son Hoai

AU - Petro, Miroslav

N1 - Created a new paradigm for the development of bio-biomaterials. RAE_import_type : Journal article RAE_uoa_type : Physics

PY - 2004/2/1

Y1 - 2004/2/1

N2 - Summary: Recently, in material science domain, combinatorial approaches in design, construction and screening of novel compounds and formulations have led to a significant acceleration of discovery and development. The versatility of polymeric materials offers a great opportunity to dial-in a desired set of performance features via a proper combination of various building blocks such as monomer units or polymer chain segments. Further enhancement comes from the formulation of the polymer into its final environment in a combinatorial way. Within the last few years, a variety of parallel polymerization, purification and formulation techniques, supported by rapid automated analyses in combination with a suite of high-throughput protocols for application-related benefit screening, were developed and successfully applied in different fields of industry. At Symyx Technologies Inc., we have integrated a variety of synthesis, screening and information tools and procedures into robust workflows, targeting discovery and development of novel polymeric materials. In addition to the performance features of the polymeric materials, controlled by their chemical, physical and mechanical properties, we can monitor interactions of polymers with a variety of molecules and substrate surfaces. That allows us to extend the applicability of the combinatorial approach towards the macromolecular delivery agents with a wide range of use in personal care, biotech and pharma areas. The current paper reports on a generic workflow developed and applied for identification of selective transport agents for targeted delivery of bioactives to human tissues.

AB - Summary: Recently, in material science domain, combinatorial approaches in design, construction and screening of novel compounds and formulations have led to a significant acceleration of discovery and development. The versatility of polymeric materials offers a great opportunity to dial-in a desired set of performance features via a proper combination of various building blocks such as monomer units or polymer chain segments. Further enhancement comes from the formulation of the polymer into its final environment in a combinatorial way. Within the last few years, a variety of parallel polymerization, purification and formulation techniques, supported by rapid automated analyses in combination with a suite of high-throughput protocols for application-related benefit screening, were developed and successfully applied in different fields of industry. At Symyx Technologies Inc., we have integrated a variety of synthesis, screening and information tools and procedures into robust workflows, targeting discovery and development of novel polymeric materials. In addition to the performance features of the polymeric materials, controlled by their chemical, physical and mechanical properties, we can monitor interactions of polymers with a variety of molecules and substrate surfaces. That allows us to extend the applicability of the combinatorial approach towards the macromolecular delivery agents with a wide range of use in personal care, biotech and pharma areas. The current paper reports on a generic workflow developed and applied for identification of selective transport agents for targeted delivery of bioactives to human tissues.

KW - biological applications of polymers • biomaterials • combinatorial chemistry • high-throughput screening • polymers

U2 - 10.1002/marc.200300229

DO - 10.1002/marc.200300229

M3 - Journal article

VL - 25

SP - 178

EP - 188

JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

SN - 1521-3927

IS - 1

ER -