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Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. / Munkley, Jennifer; Copeland, Nikki A; Moignard, Victoria et al.
In: Nucleic Acids Research, Vol. 39, No. 7, 2011, p. 2671-2677.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Munkley, J, Copeland, NA, Moignard, V, Knight, JRP, Greaves, E, Ramsbottom, SA, Pownall, ME, Southgate, J, Ainscough, JF-X & Coverley, D 2011, 'Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells', Nucleic Acids Research, vol. 39, no. 7, pp. 2671-2677. https://doi.org/10.1093/nar/gkq1190

APA

Munkley, J., Copeland, N. A., Moignard, V., Knight, J. R. P., Greaves, E., Ramsbottom, S. A., Pownall, M. E., Southgate, J., Ainscough, J. F-X., & Coverley, D. (2011). Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. Nucleic Acids Research, 39(7), 2671-2677. https://doi.org/10.1093/nar/gkq1190

Vancouver

Munkley J, Copeland NA, Moignard V, Knight JRP, Greaves E, Ramsbottom SA et al. Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. Nucleic Acids Research. 2011;39(7):2671-2677. doi: 10.1093/nar/gkq1190

Author

Munkley, Jennifer ; Copeland, Nikki A ; Moignard, Victoria et al. / Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. In: Nucleic Acids Research. 2011 ; Vol. 39, No. 7. pp. 2671-2677.

Bibtex

@article{28562393e8fc4cdea54f0e4fe1d515ae,
title = "Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells",
abstract = "Cyclin E supports pre-replication complex (pre-RC) assembly, while cyclin A-associated kinase activates DNA synthesis. We show that cyclin E, but not A, is mounted upon the nuclear matrix in sub-nuclear foci in differentiated vertebrate cells, but not in undifferentiated cells or cancer cells. In murine embryonic stem cells, Xenopus embryos and human urothelial cells, cyclin E is recruited to the nuclear matrix as cells differentiate and this can be manipulated in vitro. This suggests that pre-RC assembly becomes spatially restricted as template usage is defined. Furthermore, failure to become restricted may contribute to the plasticity of cancer cells.",
keywords = "Active Transport, Cell Nucleus, Animals, Cell Differentiation, Cell Line, Tumor, Cells, Cultured, Cyclin E, Humans, Mice, Neoplasms, Nuclear Matrix, Protein Transport, Xenopus laevis",
author = "Jennifer Munkley and Copeland, {Nikki A} and Victoria Moignard and Knight, {John R P} and Erin Greaves and Ramsbottom, {Simon A} and Pownall, {Mary E} and Jennifer Southgate and Ainscough, {Justin F-X} and Dawn Coverley",
year = "2011",
doi = "10.1093/nar/gkq1190",
language = "English",
volume = "39",
pages = "2671--2677",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells

AU - Munkley, Jennifer

AU - Copeland, Nikki A

AU - Moignard, Victoria

AU - Knight, John R P

AU - Greaves, Erin

AU - Ramsbottom, Simon A

AU - Pownall, Mary E

AU - Southgate, Jennifer

AU - Ainscough, Justin F-X

AU - Coverley, Dawn

PY - 2011

Y1 - 2011

N2 - Cyclin E supports pre-replication complex (pre-RC) assembly, while cyclin A-associated kinase activates DNA synthesis. We show that cyclin E, but not A, is mounted upon the nuclear matrix in sub-nuclear foci in differentiated vertebrate cells, but not in undifferentiated cells or cancer cells. In murine embryonic stem cells, Xenopus embryos and human urothelial cells, cyclin E is recruited to the nuclear matrix as cells differentiate and this can be manipulated in vitro. This suggests that pre-RC assembly becomes spatially restricted as template usage is defined. Furthermore, failure to become restricted may contribute to the plasticity of cancer cells.

AB - Cyclin E supports pre-replication complex (pre-RC) assembly, while cyclin A-associated kinase activates DNA synthesis. We show that cyclin E, but not A, is mounted upon the nuclear matrix in sub-nuclear foci in differentiated vertebrate cells, but not in undifferentiated cells or cancer cells. In murine embryonic stem cells, Xenopus embryos and human urothelial cells, cyclin E is recruited to the nuclear matrix as cells differentiate and this can be manipulated in vitro. This suggests that pre-RC assembly becomes spatially restricted as template usage is defined. Furthermore, failure to become restricted may contribute to the plasticity of cancer cells.

KW - Active Transport, Cell Nucleus

KW - Animals

KW - Cell Differentiation

KW - Cell Line, Tumor

KW - Cells, Cultured

KW - Cyclin E

KW - Humans

KW - Mice

KW - Neoplasms

KW - Nuclear Matrix

KW - Protein Transport

KW - Xenopus laevis

U2 - 10.1093/nar/gkq1190

DO - 10.1093/nar/gkq1190

M3 - Journal article

C2 - 21109536

VL - 39

SP - 2671

EP - 2677

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 7

ER -