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Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. / Zhang, Zijian; Williams, Bryan M.; Zheng, Yalin et al.
In: Coatings, Vol. 9, No. 5, 326, 17.05.2019.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Zhang, Z, Williams, BM, Zheng, Y, Lin, H & Shen, Y 2019, 'Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography', Coatings, vol. 9, no. 5, 326. https://doi.org/10.3390/coatings9050326

APA

Zhang, Z., Williams, B. M., Zheng, Y., Lin, H., & Shen, Y. (2019). Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. Coatings, 9(5), Article 326. https://doi.org/10.3390/coatings9050326

Vancouver

Zhang Z, Williams BM, Zheng Y, Lin H, Shen Y. Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. Coatings. 2019 May 17;9(5):326. doi: 10.3390/coatings9050326

Author

Zhang, Zijian ; Williams, Bryan M. ; Zheng, Yalin et al. / Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. In: Coatings. 2019 ; Vol. 9, No. 5.

Bibtex

@article{5c247db68df541e7aff3e069f6001783,
title = "Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography",
abstract = "Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets.",
keywords = "pharmaceutical film coating, thin coating, 500-mg paracetamol tablet, GSK Panadol, generic paracetamol, optical coherence tomography, image segmentation, differentiation",
author = "Zijian Zhang and Williams, {Bryan M.} and Yalin Zheng and Hungyen Lin and Yaochun Shen",
year = "2019",
month = may,
day = "17",
doi = "10.3390/coatings9050326",
language = "English",
volume = "9",
journal = "Coatings",
issn = "2079-6412",
publisher = "MDPI AG",
number = "5",

}

RIS

TY - JOUR

T1 - Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography

AU - Zhang, Zijian

AU - Williams, Bryan M.

AU - Zheng, Yalin

AU - Lin, Hungyen

AU - Shen, Yaochun

PY - 2019/5/17

Y1 - 2019/5/17

N2 - Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets.

AB - Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets.

KW - pharmaceutical film coating

KW - thin coating

KW - 500-mg paracetamol tablet

KW - GSK Panadol

KW - generic paracetamol

KW - optical coherence tomography

KW - image segmentation

KW - differentiation

U2 - 10.3390/coatings9050326

DO - 10.3390/coatings9050326

M3 - Journal article

VL - 9

JO - Coatings

JF - Coatings

SN - 2079-6412

IS - 5

M1 - 326

ER -