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Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Zijian Zhang
  • Bryan M. Williams
  • Yalin Zheng
  • Hungyen Lin
  • Yaochun Shen
Article number326
<mark>Journal publication date</mark>17/05/2019
Issue number5
Number of pages8
Publication StatusPublished
<mark>Original language</mark>English


Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets.