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Early impact of rotavirus vaccination in a large paediatric hospital in the UK

Research output: Contribution to journalJournal article

  • D. Hungerford
  • Jonathan M. Read
  • R. P. D. Cooke
  • R. Vivancos
  • M. Iturriza-Gómara
  • D. J. Allen
  • N. French
  • N. Cunliffe
<mark>Journal publication date</mark>06/2016
<mark>Journal</mark>Journal of Hospital Infection
Issue number2
Number of pages4
Pages (from-to)117-120
Publication statusPublished
Early online date31/12/15
Original languageEnglish


The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.