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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Early impact of rotavirus vaccination in a large paediatric hospital in the UK
AU - Hungerford, D.
AU - Read, Jonathan M.
AU - Cooke, R. P. D.
AU - Vivancos, R.
AU - Iturriza-Gómara, M.
AU - Allen, D. J.
AU - French, N.
AU - Cunliffe, N.
N1 - Copyright © 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
PY - 2016/6
Y1 - 2016/6
N2 - The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.
AB - The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.
KW - Epidemiology
KW - Healthcare-associated infection
KW - Rotavirus
KW - Vaccination
U2 - 10.1016/j.jhin.2015.12.010
DO - 10.1016/j.jhin.2015.12.010
M3 - Journal article
C2 - 26876744
VL - 93
SP - 117
EP - 120
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
SN - 0195-6701
IS - 2
ER -