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Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs. / Mousavi, Seyed; Harper, Garry; Municoy, Sofia et al.
In: Macromolecular Materials and Engineering, Vol. 305, No. 6, 2000130, 01.06.2020.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Mousavi, S, Harper, G, Municoy, S, Ashton, M, Townsend, D, Alsharif, G, Oikonomou, V, Au-Yong, S, Murdock, B, Akien, G, Halcovitch, N, Baldock, S, Fazilati, M, Kolosov, O, Robinson, B, Desimone, M & Hardy, J 2020, 'Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs', Macromolecular Materials and Engineering, vol. 305, no. 6, 2000130. https://doi.org/10.1002/mame.202000130

APA

Mousavi, S., Harper, G., Municoy, S., Ashton, M., Townsend, D., Alsharif, G., Oikonomou, V., Au-Yong, S., Murdock, B., Akien, G., Halcovitch, N., Baldock, S., Fazilati, M., Kolosov, O., Robinson, B., Desimone, M., & Hardy, J. (2020). Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs. Macromolecular Materials and Engineering, 305(6), Article 2000130. https://doi.org/10.1002/mame.202000130

Vancouver

Mousavi S, Harper G, Municoy S, Ashton M, Townsend D, Alsharif G et al. Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs. Macromolecular Materials and Engineering. 2020 Jun 1;305(6):2000130. Epub 2020 May 17. doi: 10.1002/mame.202000130

Author

Mousavi, Seyed ; Harper, Garry ; Municoy, Sofia et al. / Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs. In: Macromolecular Materials and Engineering. 2020 ; Vol. 305, No. 6.

Bibtex

@article{01aa870a0b094c1bac454958ea8e2650,
title = "Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs",
abstract = "Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film‐based drug delivery devices is described. Casting aqueous solutions of Bombyx mori silk fibroin, followed by drying and annealing to impart β‐sheets to the silk fibroin, assure that the materials are stable for further processing in water; and the silk fibroin films are rendered conductive by generating an interpenetrating network of a copolymer of pyrrole and 3‐amino‐4‐hydroxybenzenesulfonic acid in the silk fibroin matrix (characterized by a variety of techniques including circular dichroism, Fourier‐transform infrared spectroscopy, nuclear magnetic resonance, Raman spectroscopy, resistance measurements, scanning electron microscopy‐energy dispersive X‐ray spectroscopy, thermogravimetric analysis, X‐ray diffraction, and X‐ray photoelectron spectroscopy). Fibroblasts adhere on the surface of the biomaterials (viability assessed using an (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay and visualized using a confocal microscope), and a fluorescently labeled drug (Texas‐Red Gentamicin) can be loaded electrochemically and released (µg cm−2 quantities) in response to the application of an electrical stimulus.",
keywords = "silk, biomaterials, electroactive, Drug delivery",
author = "Seyed Mousavi and Garry Harper and Sofia Municoy and Mark Ashton and David Townsend and Ghazi Alsharif and Vasileios Oikonomou and Sophie Au-Yong and Beth Murdock and Geoffrey Akien and Nathan Halcovitch and Sara Baldock and Mohamad Fazilati and Oleg Kolosov and Benjamin Robinson and Martin Desimone and John Hardy",
year = "2020",
month = jun,
day = "1",
doi = "10.1002/mame.202000130",
language = "English",
volume = "305",
journal = "Macromolecular Materials and Engineering",
issn = "1438-7492",
publisher = "Wiley",
number = "6",

}

RIS

TY - JOUR

T1 - Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs

AU - Mousavi, Seyed

AU - Harper, Garry

AU - Municoy, Sofia

AU - Ashton, Mark

AU - Townsend, David

AU - Alsharif, Ghazi

AU - Oikonomou, Vasileios

AU - Au-Yong, Sophie

AU - Murdock, Beth

AU - Akien, Geoffrey

AU - Halcovitch, Nathan

AU - Baldock, Sara

AU - Fazilati, Mohamad

AU - Kolosov, Oleg

AU - Robinson, Benjamin

AU - Desimone, Martin

AU - Hardy, John

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film‐based drug delivery devices is described. Casting aqueous solutions of Bombyx mori silk fibroin, followed by drying and annealing to impart β‐sheets to the silk fibroin, assure that the materials are stable for further processing in water; and the silk fibroin films are rendered conductive by generating an interpenetrating network of a copolymer of pyrrole and 3‐amino‐4‐hydroxybenzenesulfonic acid in the silk fibroin matrix (characterized by a variety of techniques including circular dichroism, Fourier‐transform infrared spectroscopy, nuclear magnetic resonance, Raman spectroscopy, resistance measurements, scanning electron microscopy‐energy dispersive X‐ray spectroscopy, thermogravimetric analysis, X‐ray diffraction, and X‐ray photoelectron spectroscopy). Fibroblasts adhere on the surface of the biomaterials (viability assessed using an (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay and visualized using a confocal microscope), and a fluorescently labeled drug (Texas‐Red Gentamicin) can be loaded electrochemically and released (µg cm−2 quantities) in response to the application of an electrical stimulus.

AB - Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film‐based drug delivery devices is described. Casting aqueous solutions of Bombyx mori silk fibroin, followed by drying and annealing to impart β‐sheets to the silk fibroin, assure that the materials are stable for further processing in water; and the silk fibroin films are rendered conductive by generating an interpenetrating network of a copolymer of pyrrole and 3‐amino‐4‐hydroxybenzenesulfonic acid in the silk fibroin matrix (characterized by a variety of techniques including circular dichroism, Fourier‐transform infrared spectroscopy, nuclear magnetic resonance, Raman spectroscopy, resistance measurements, scanning electron microscopy‐energy dispersive X‐ray spectroscopy, thermogravimetric analysis, X‐ray diffraction, and X‐ray photoelectron spectroscopy). Fibroblasts adhere on the surface of the biomaterials (viability assessed using an (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay and visualized using a confocal microscope), and a fluorescently labeled drug (Texas‐Red Gentamicin) can be loaded electrochemically and released (µg cm−2 quantities) in response to the application of an electrical stimulus.

KW - silk

KW - biomaterials

KW - electroactive

KW - Drug delivery

U2 - 10.1002/mame.202000130

DO - 10.1002/mame.202000130

M3 - Journal article

VL - 305

JO - Macromolecular Materials and Engineering

JF - Macromolecular Materials and Engineering

SN - 1438-7492

IS - 6

M1 - 2000130

ER -