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FALC stromal cells define a unique immunological niche for the surveillance of serous cavities

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FALC stromal cells define a unique immunological niche for the surveillance of serous cavities. / Jackson-Jones, Lucy; Benezech, Cecile.

In: Current opinion in immunology, Vol. 64, 01.06.2020, p. 42-49.

Research output: Contribution to journalReview article

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Jackson-Jones, Lucy ; Benezech, Cecile. / FALC stromal cells define a unique immunological niche for the surveillance of serous cavities. In: Current opinion in immunology. 2020 ; Vol. 64. pp. 42-49.

Bibtex

@article{b5578b2216614e879da995384ea2df62,
title = "FALC stromal cells define a unique immunological niche for the surveillance of serous cavities",
abstract = "The serous cavities contain specialised adipose tissues which house small clusters of immune cells known as fat-associated lymphoid clusters (FALCs). The continuous flow of fluid from the serous cavities through FALCs makes them unique niches for the clearance of fluid phase contaminants and initiation of locally protective immune responses during infection and inflammation. Development, and activation of FALCs both at homeostasis and following inflammation are co-ordinated by the close interaction of mesothelial and fibroblastic stromal cell populations with immune cells. In this review we discuss recent developments in FALC stromal cell biology and highlight key interactions that occur between FALC stroma and immune cells. ",
author = "Lucy Jackson-Jones and Cecile Benezech",
year = "2020",
month = jun
day = "1",
doi = "10.1016/j.coi.2020.03.008",
language = "English",
volume = "64",
pages = "42--49",
journal = "Current opinion in immunology",
issn = "0952-7915",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - FALC stromal cells define a unique immunological niche for the surveillance of serous cavities

AU - Jackson-Jones, Lucy

AU - Benezech, Cecile

PY - 2020/6/1

Y1 - 2020/6/1

N2 - The serous cavities contain specialised adipose tissues which house small clusters of immune cells known as fat-associated lymphoid clusters (FALCs). The continuous flow of fluid from the serous cavities through FALCs makes them unique niches for the clearance of fluid phase contaminants and initiation of locally protective immune responses during infection and inflammation. Development, and activation of FALCs both at homeostasis and following inflammation are co-ordinated by the close interaction of mesothelial and fibroblastic stromal cell populations with immune cells. In this review we discuss recent developments in FALC stromal cell biology and highlight key interactions that occur between FALC stroma and immune cells.

AB - The serous cavities contain specialised adipose tissues which house small clusters of immune cells known as fat-associated lymphoid clusters (FALCs). The continuous flow of fluid from the serous cavities through FALCs makes them unique niches for the clearance of fluid phase contaminants and initiation of locally protective immune responses during infection and inflammation. Development, and activation of FALCs both at homeostasis and following inflammation are co-ordinated by the close interaction of mesothelial and fibroblastic stromal cell populations with immune cells. In this review we discuss recent developments in FALC stromal cell biology and highlight key interactions that occur between FALC stroma and immune cells.

U2 - 10.1016/j.coi.2020.03.008

DO - 10.1016/j.coi.2020.03.008

M3 - Review article

VL - 64

SP - 42

EP - 49

JO - Current opinion in immunology

JF - Current opinion in immunology

SN - 0952-7915

ER -