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Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

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<mark>Journal publication date</mark>21/03/2012
<mark>Journal</mark>Chemical Communications
Issue number24
Volume48
Number of pages3
Pages (from-to)2976-8
Publication StatusPublished
<mark>Original language</mark>English

Abstract

The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.