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Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

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Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks. / Madine, Jillian; Davies, Hannah A; Shaw, Christopher et al.

In: Chemical Communications, Vol. 48, No. 24, 21.03.2012, p. 2976-8.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Madine J, Davies HA, Shaw C, Hamley IW, Middleton DA. Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks. Chemical Communications. 2012 Mar 21;48(24):2976-8. doi: 10.1039/c2cc17118j

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Madine, Jillian ; Davies, Hannah A ; Shaw, Christopher et al. / Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks. In: Chemical Communications. 2012 ; Vol. 48, No. 24. pp. 2976-8.

Bibtex

@article{1b694250227e4fbca626746ab7a4251d,
title = "Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks",
abstract = "The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.",
keywords = "Amyloid beta-Peptides, Magnetic Resonance Spectroscopy, Microscopy, Electron, Transmission, Nanotubes, Peptide Fragments, Protein Structure, Secondary, Spectroscopy, Fourier Transform Infrared",
author = "Jillian Madine and Davies, {Hannah A} and Christopher Shaw and Hamley, {Ian W} and Middleton, {David A}",
year = "2012",
month = mar,
day = "21",
doi = "10.1039/c2cc17118j",
language = "English",
volume = "48",
pages = "2976--8",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "24",

}

RIS

TY - JOUR

T1 - Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

AU - Madine, Jillian

AU - Davies, Hannah A

AU - Shaw, Christopher

AU - Hamley, Ian W

AU - Middleton, David A

PY - 2012/3/21

Y1 - 2012/3/21

N2 - The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.

AB - The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.

KW - Amyloid beta-Peptides

KW - Magnetic Resonance Spectroscopy

KW - Microscopy, Electron, Transmission

KW - Nanotubes

KW - Peptide Fragments

KW - Protein Structure, Secondary

KW - Spectroscopy, Fourier Transform Infrared

U2 - 10.1039/c2cc17118j

DO - 10.1039/c2cc17118j

M3 - Journal article

C2 - 22328992

VL - 48

SP - 2976

EP - 2978

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 24

ER -