Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks
AU - Madine, Jillian
AU - Davies, Hannah A
AU - Shaw, Christopher
AU - Hamley, Ian W
AU - Middleton, David A
PY - 2012/3/21
Y1 - 2012/3/21
N2 - The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.
AB - The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.
KW - Amyloid beta-Peptides
KW - Magnetic Resonance Spectroscopy
KW - Microscopy, Electron, Transmission
KW - Nanotubes
KW - Peptide Fragments
KW - Protein Structure, Secondary
KW - Spectroscopy, Fourier Transform Infrared
U2 - 10.1039/c2cc17118j
DO - 10.1039/c2cc17118j
M3 - Journal article
C2 - 22328992
VL - 48
SP - 2976
EP - 2978
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 24
ER -