Home > Research > Publications & Outputs > Flagellum function and assembly during the Leis...
View graph of relations

Flagellum function and assembly during the Leishmania life cycle.

Research output: Contribution to journalJournal article

Published
Close
<mark>Journal publication date</mark>08/2010
<mark>Journal</mark>Current Opinion in Microbiology
Issue number4
Volume13
Number of pages7
Pages (from-to)473-479
Publication statusPublished
Original languageEnglish

Abstract

During a complex digenetic life cycle flagellated Leishmania parasites alternate between promastigote and amastigote forms which differ significantly in cellular morphology and flagellum length. Recent studies have provided important new insights into mechanisms by which Leishmania regulate expression of genes required for flagellum assembly, and mechanisms used to modify flagellum length. While the critical role of the promastigote flagellum in parasite biology has long been appreciated, the importance of the amastigote flagellum has often been disregarded. However, recent work suggests that the 'rudimentary' amastigote flagellum may serve indispensable roles in cellular organisation, and/or sensory perception, which are critical for intracellular survival of Leishmania within host macrophages.