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Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

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<mark>Journal publication date</mark>10/2010
<mark>Journal</mark>Diabetes, Obesity and Metabolism
Issue number10
Volume12
Number of pages9
Pages (from-to)891-899
Publication statusPublished
Original languageEnglish

Abstract

Liraglutide is a long-acting glucagon-like peptide-1 (GLP-1) mimetic which is a treatment option for type 2 diabetes. GLP-1 peptides, including Liraglutide, cross the blood-brain barrier and may additionally act to improve brain function. The present study tested the hypothesis that, in addition to its antihyperglycaemic actions, peripheral administration of Liraglutide exerts positive actions on cognitive function in mice with high fat dietary-induced obesity and insulin resistance.

Bibliographic note

© 2010 Blackwell Publishing Ltd.