Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance
AU - Porter, D. W.
AU - Kerr, B. D.
AU - Flatt, P. R.
AU - Hölscher, Christian
AU - Gault, V. A.
N1 - © 2010 Blackwell Publishing Ltd.
PY - 2010/10
Y1 - 2010/10
N2 - Liraglutide is a long-acting glucagon-like peptide-1 (GLP-1) mimetic which is a treatment option for type 2 diabetes. GLP-1 peptides, including Liraglutide, cross the blood-brain barrier and may additionally act to improve brain function. The present study tested the hypothesis that, in addition to its antihyperglycaemic actions, peripheral administration of Liraglutide exerts positive actions on cognitive function in mice with high fat dietary-induced obesity and insulin resistance.
AB - Liraglutide is a long-acting glucagon-like peptide-1 (GLP-1) mimetic which is a treatment option for type 2 diabetes. GLP-1 peptides, including Liraglutide, cross the blood-brain barrier and may additionally act to improve brain function. The present study tested the hypothesis that, in addition to its antihyperglycaemic actions, peripheral administration of Liraglutide exerts positive actions on cognitive function in mice with high fat dietary-induced obesity and insulin resistance.
KW - Animals
KW - Blood Glucose
KW - Cognition
KW - Diabetes Mellitus, Type 2
KW - Glucagon-Like Peptide 1
KW - Hypoglycemic Agents
KW - Insulin Resistance
KW - Male
KW - Memory
KW - Mice
KW - Obesity
U2 - 10.1111/j.1463-1326.2010.01259.x
DO - 10.1111/j.1463-1326.2010.01259.x
M3 - Journal article
C2 - 20920042
VL - 12
SP - 891
EP - 899
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1463-1326
IS - 10
ER -