In the last decade of his life, Jacques Derrida articulated “autoimmunity” as the safeguarding mechanism with which an entity believing it has been infiltrated with a threatening “other” reacts against itself. Using Derrida’s analysis of politically reactionary forms of autoimmunity, this essay analyses how Houellebecq’s most recent extra-textual reactionary provocations are embedded in the techno-scientific and posthuman vision of his early fictions. Extending Derrida’s metaphor of autoimmunity to Houellebecq’s literary and authorial strategies, I argue that Houellebecq’s willingness to destroy the very channels of his literary and extra-textual provocations is rooted in the extension of neoliberalism to the private and biological spheres of life described in his fictions.