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Gold (I) Complexes Derived From Alkynoxy-substituted Anthraquinones: Syntheses, Luminescence, Cytotoxicity and Cell Imaging Studies,

Research output: Contribution to journalJournal article

Published

  • Rebeca G. Balasingham
  • Catrin F. Williams
  • Huw J. Mottram
  • Michael Coogan
  • Simon J. A. Pope

Associated organisational unit

Journal publication date16/08/2012
JournalOrganometallics
Journal number16
Volume31
Number of pages9
Pages5835-5843
Original languageEnglish

Abstract

A series of mono- and dimetallic Au(I) triphenylphosphine complexes derived from 1,2-, 1,4-, and 1,8-dialkynyloxyanthraquinone have been prepared. The photophysical and cytotoxic behavior of the ligands and complexes have been explored, with all of the complexes showing both appreciable cytotoxicity against the MCF-7 carcinoma cell line and useful room-temperature anthraquinone-based visible luminescence, which allowed their successful application as fluorophores in cell imaging microscopy. The implications of the photophysical and toxicological properties for the design and investigation of gold-based anticancer agents are discussed.