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Gold (I) Complexes Derived From Alkynoxy-substituted Anthraquinones: Syntheses, Luminescence, Cytotoxicity and Cell Imaging Studies, / Balasingham, Rebeca G. ; Williams, Catrin F.; Mottram, Huw J. et al.
In:
Organometallics, Vol. 31, No. 16, 16.08.2012, p. 5835-5843.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Harvard
Balasingham, RG, Williams, CF, Mottram, HJ
, Coogan, M & Pope, SJA 2012, '
Gold (I) Complexes Derived From Alkynoxy-substituted Anthraquinones: Syntheses, Luminescence, Cytotoxicity and Cell Imaging Studies,',
Organometallics, vol. 31, no. 16, pp. 5835-5843.
https://doi.org/10.1021/om300475yAPA
Balasingham, R. G., Williams, C. F., Mottram, H. J.
, Coogan, M., & Pope, S. J. A. (2012).
Gold (I) Complexes Derived From Alkynoxy-substituted Anthraquinones: Syntheses, Luminescence, Cytotoxicity and Cell Imaging Studies, Organometallics,
31(16), 5835-5843.
https://doi.org/10.1021/om300475yVancouver
Author
Bibtex
@article{754a711821124e0e81eee814b00f8dab,
title = "Gold (I) Complexes Derived From Alkynoxy-substituted Anthraquinones: Syntheses, Luminescence, Cytotoxicity and Cell Imaging Studies,",
abstract = "A series of mono- and dimetallic Au(I) triphenylphosphine complexes derived from 1,2-, 1,4-, and 1,8-dialkynyloxyanthraquinone have been prepared. The photophysical and cytotoxic behavior of the ligands and complexes have been explored, with all of the complexes showing both appreciable cytotoxicity against the MCF-7 carcinoma cell line and useful room-temperature anthraquinone-based visible luminescence, which allowed their successful application as fluorophores in cell imaging microscopy. The implications of the photophysical and toxicological properties for the design and investigation of gold-based anticancer agents are discussed.",
author = "Balasingham, {Rebeca G.} and Williams, {Catrin F.} and Mottram, {Huw J.} and Michael Coogan and Pope, {Simon J. A.}",
year = "2012",
month = aug,
day = "16",
doi = "10.1021/om300475y",
language = "English",
volume = "31",
pages = "5835--5843",
journal = "Organometallics",
issn = "1520-6041",
publisher = "American Chemical Society",
number = "16",
}
RIS
TY - JOUR
T1 - Gold (I) Complexes Derived From Alkynoxy-substituted Anthraquinones: Syntheses, Luminescence, Cytotoxicity and Cell Imaging Studies,
AU - Balasingham, Rebeca G.
AU - Williams, Catrin F.
AU - Mottram, Huw J.
AU - Coogan, Michael
AU - Pope, Simon J. A.
PY - 2012/8/16
Y1 - 2012/8/16
N2 - A series of mono- and dimetallic Au(I) triphenylphosphine complexes derived from 1,2-, 1,4-, and 1,8-dialkynyloxyanthraquinone have been prepared. The photophysical and cytotoxic behavior of the ligands and complexes have been explored, with all of the complexes showing both appreciable cytotoxicity against the MCF-7 carcinoma cell line and useful room-temperature anthraquinone-based visible luminescence, which allowed their successful application as fluorophores in cell imaging microscopy. The implications of the photophysical and toxicological properties for the design and investigation of gold-based anticancer agents are discussed.
AB - A series of mono- and dimetallic Au(I) triphenylphosphine complexes derived from 1,2-, 1,4-, and 1,8-dialkynyloxyanthraquinone have been prepared. The photophysical and cytotoxic behavior of the ligands and complexes have been explored, with all of the complexes showing both appreciable cytotoxicity against the MCF-7 carcinoma cell line and useful room-temperature anthraquinone-based visible luminescence, which allowed their successful application as fluorophores in cell imaging microscopy. The implications of the photophysical and toxicological properties for the design and investigation of gold-based anticancer agents are discussed.
U2 - 10.1021/om300475y
DO - 10.1021/om300475y
M3 - Journal article
VL - 31
SP - 5835
EP - 5843
JO - Organometallics
JF - Organometallics
SN - 1520-6041
IS - 16
ER -
