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Gold nanoparticles as a substrate in bio-analytical near-infrared surface-enhanced Raman spectroscopy

Research output: Contribution to journalJournal article

Published
<mark>Journal publication date</mark>2015
<mark>Journal</mark>Analyst
Issue number9
Volume140
Number of pages8
Pages (from-to)3090-3097
Publication StatusPublished
Early online date17/03/15
<mark>Original language</mark>English

Abstract

As biospectroscopy techniques continue to be developed for screening or diagnosis within a point-ofcare setting, an important development for this field will be high-throughput optimization. For many of these techniques, it is therefore necessary to adapt and develop parameters to generate a robust yet simple approach delivering high-quality spectra from biological samples. Specifically, this is important for surface-enhanced Raman spectroscopy (SERS) wherein there are multiple variables that can be optimised to achieve an enhancement of the Raman signal from a sample. One hypothesis is that "large" diameter (>100 nm) gold nanoparticles provide a greater enhancement at near-infrared (NIR) and infrared (IR) wavelengths than those