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Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology

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<mark>Journal publication date</mark>1986
<mark>Journal</mark>Journal of Neurology, Neurosurgery and Psychiatry
Issue number8
Volume49
Number of pages7
Pages (from-to)886-892
Publication statusPublished
Original languageEnglish

Abstract

Frontal and temporal cortical tissue from the brains of elderly cases of Down's syndrome was used to make preparations of neuronal cell bodies containing senile plaque cores. Polarisation microscopy revealed normal "classical" plaque cores, and also a high proportion of unusual "amorphous" plaque cores which we have not seen in Alzheimer's disease. These two forms were easily distinguished by electron microscopy. This suggests that late Down's syndrome may not be an exact model for Alzheimer's disease.