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Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. / Allsop, D; Kidd, M; Landon, M et al.
In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 49, No. 8, 1986, p. 886-892.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Allsop, D, Kidd, M, Landon, M & Tomlinson, A 1986, 'Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology', Journal of Neurology, Neurosurgery and Psychiatry, vol. 49, no. 8, pp. 886-892.

APA

Allsop, D., Kidd, M., Landon, M., & Tomlinson, A. (1986). Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. Journal of Neurology, Neurosurgery and Psychiatry, 49(8), 886-892.

Vancouver

Allsop D, Kidd M, Landon M, Tomlinson A. Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. Journal of Neurology, Neurosurgery and Psychiatry. 1986;49(8):886-892.

Author

Allsop, D ; Kidd, M ; Landon, M et al. / Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. In: Journal of Neurology, Neurosurgery and Psychiatry. 1986 ; Vol. 49, No. 8. pp. 886-892.

Bibtex

@article{1425d4c106694d2bbd3dd7a5217053d4,
title = "Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology",
abstract = "Frontal and temporal cortical tissue from the brains of elderly cases of Down's syndrome was used to make preparations of neuronal cell bodies containing senile plaque cores. Polarisation microscopy revealed normal {"}classical{"} plaque cores, and also a high proportion of unusual {"}amorphous{"} plaque cores which we have not seen in Alzheimer's disease. These two forms were easily distinguished by electron microscopy. This suggests that late Down's syndrome may not be an exact model for Alzheimer's disease.",
keywords = "Alzheimer Disease, Down Syndrome, Frontal Lobe, Humans, Microscopy, Electron, Temporal Lobe",
author = "D Allsop and M Kidd and M Landon and A Tomlinson",
year = "1986",
language = "English",
volume = "49",
pages = "886--892",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology

AU - Allsop, D

AU - Kidd, M

AU - Landon, M

AU - Tomlinson, A

PY - 1986

Y1 - 1986

N2 - Frontal and temporal cortical tissue from the brains of elderly cases of Down's syndrome was used to make preparations of neuronal cell bodies containing senile plaque cores. Polarisation microscopy revealed normal "classical" plaque cores, and also a high proportion of unusual "amorphous" plaque cores which we have not seen in Alzheimer's disease. These two forms were easily distinguished by electron microscopy. This suggests that late Down's syndrome may not be an exact model for Alzheimer's disease.

AB - Frontal and temporal cortical tissue from the brains of elderly cases of Down's syndrome was used to make preparations of neuronal cell bodies containing senile plaque cores. Polarisation microscopy revealed normal "classical" plaque cores, and also a high proportion of unusual "amorphous" plaque cores which we have not seen in Alzheimer's disease. These two forms were easily distinguished by electron microscopy. This suggests that late Down's syndrome may not be an exact model for Alzheimer's disease.

KW - Alzheimer Disease

KW - Down Syndrome

KW - Frontal Lobe

KW - Humans

KW - Microscopy, Electron

KW - Temporal Lobe

M3 - Journal article

C2 - 2943873

VL - 49

SP - 886

EP - 892

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 8

ER -