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Mitotic inhibition of clathrin-mediated endocytosis

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Mitotic inhibition of clathrin-mediated endocytosis. / Fielding, Andrew B.
In: Cellular and Molecular Life Sciences : CMLS, Vol. 70, No. 18, 09.2013, p. 3423-3433.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Fielding, AB 2013, 'Mitotic inhibition of clathrin-mediated endocytosis', Cellular and Molecular Life Sciences : CMLS, vol. 70, no. 18, pp. 3423-3433. https://doi.org/10.1007/s00018-012-1250-8

APA

Fielding, A. B. (2013). Mitotic inhibition of clathrin-mediated endocytosis. Cellular and Molecular Life Sciences : CMLS, 70(18), 3423-3433. https://doi.org/10.1007/s00018-012-1250-8

Vancouver

Fielding AB. Mitotic inhibition of clathrin-mediated endocytosis. Cellular and Molecular Life Sciences : CMLS. 2013 Sept;70(18):3423-3433. doi: 10.1007/s00018-012-1250-8

Author

Fielding, Andrew B. / Mitotic inhibition of clathrin-mediated endocytosis. In: Cellular and Molecular Life Sciences : CMLS. 2013 ; Vol. 70, No. 18. pp. 3423-3433.

Bibtex

@article{e505b918d87145d4ba13e1b527506d41,
title = "Mitotic inhibition of clathrin-mediated endocytosis",
abstract = "Endocytosis and mitosis are fundamental processes in a cell's life. Nearly 50 years of research suggest that these processes are linked and that endocytosis is shut down as cells undergo the early stages of mitosis. Precisely how this occurs at the molecular level is an open question. In this review, we summarize the early work characterizing the inhibition of clathrin-mediated endocytosis and discuss recent challenges to this established concept. We also set out four proposed mechanisms for the inhibition: mitotic phosphorylation of endocytic proteins, altered membrane tension, moonlighting of endocytic proteins, and a mitotic spindle-dependent mechanism. Finally, we speculate on the functional consequences of endocytic shutdown during mitosis and where an understanding of the mechanism of inhibition will lead us in the future.",
keywords = "Animals, Biological Transport, Cell Cycle, Cell Division, Cell Membrane, Clathrin, Endocytosis, Humans, Mice, Microtubules, Mitosis, Phosphorylation, Spindle Apparatus, Transferrin, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Fielding, {Andrew B.}",
year = "2013",
month = sep,
doi = "10.1007/s00018-012-1250-8",
language = "English",
volume = "70",
pages = "3423--3433",
journal = "Cellular and Molecular Life Sciences : CMLS",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "18",

}

RIS

TY - JOUR

T1 - Mitotic inhibition of clathrin-mediated endocytosis

AU - Fielding, Andrew B.

PY - 2013/9

Y1 - 2013/9

N2 - Endocytosis and mitosis are fundamental processes in a cell's life. Nearly 50 years of research suggest that these processes are linked and that endocytosis is shut down as cells undergo the early stages of mitosis. Precisely how this occurs at the molecular level is an open question. In this review, we summarize the early work characterizing the inhibition of clathrin-mediated endocytosis and discuss recent challenges to this established concept. We also set out four proposed mechanisms for the inhibition: mitotic phosphorylation of endocytic proteins, altered membrane tension, moonlighting of endocytic proteins, and a mitotic spindle-dependent mechanism. Finally, we speculate on the functional consequences of endocytic shutdown during mitosis and where an understanding of the mechanism of inhibition will lead us in the future.

AB - Endocytosis and mitosis are fundamental processes in a cell's life. Nearly 50 years of research suggest that these processes are linked and that endocytosis is shut down as cells undergo the early stages of mitosis. Precisely how this occurs at the molecular level is an open question. In this review, we summarize the early work characterizing the inhibition of clathrin-mediated endocytosis and discuss recent challenges to this established concept. We also set out four proposed mechanisms for the inhibition: mitotic phosphorylation of endocytic proteins, altered membrane tension, moonlighting of endocytic proteins, and a mitotic spindle-dependent mechanism. Finally, we speculate on the functional consequences of endocytic shutdown during mitosis and where an understanding of the mechanism of inhibition will lead us in the future.

KW - Animals

KW - Biological Transport

KW - Cell Cycle

KW - Cell Division

KW - Cell Membrane

KW - Clathrin

KW - Endocytosis

KW - Humans

KW - Mice

KW - Microtubules

KW - Mitosis

KW - Phosphorylation

KW - Spindle Apparatus

KW - Transferrin

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1007/s00018-012-1250-8

DO - 10.1007/s00018-012-1250-8

M3 - Journal article

C2 - 23307073

VL - 70

SP - 3423

EP - 3433

JO - Cellular and Molecular Life Sciences : CMLS

JF - Cellular and Molecular Life Sciences : CMLS

SN - 1420-682X

IS - 18

ER -