Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Mitotic inhibition of clathrin-mediated endocytosis
AU - Fielding, Andrew B.
PY - 2013/9
Y1 - 2013/9
N2 - Endocytosis and mitosis are fundamental processes in a cell's life. Nearly 50 years of research suggest that these processes are linked and that endocytosis is shut down as cells undergo the early stages of mitosis. Precisely how this occurs at the molecular level is an open question. In this review, we summarize the early work characterizing the inhibition of clathrin-mediated endocytosis and discuss recent challenges to this established concept. We also set out four proposed mechanisms for the inhibition: mitotic phosphorylation of endocytic proteins, altered membrane tension, moonlighting of endocytic proteins, and a mitotic spindle-dependent mechanism. Finally, we speculate on the functional consequences of endocytic shutdown during mitosis and where an understanding of the mechanism of inhibition will lead us in the future.
AB - Endocytosis and mitosis are fundamental processes in a cell's life. Nearly 50 years of research suggest that these processes are linked and that endocytosis is shut down as cells undergo the early stages of mitosis. Precisely how this occurs at the molecular level is an open question. In this review, we summarize the early work characterizing the inhibition of clathrin-mediated endocytosis and discuss recent challenges to this established concept. We also set out four proposed mechanisms for the inhibition: mitotic phosphorylation of endocytic proteins, altered membrane tension, moonlighting of endocytic proteins, and a mitotic spindle-dependent mechanism. Finally, we speculate on the functional consequences of endocytic shutdown during mitosis and where an understanding of the mechanism of inhibition will lead us in the future.
KW - Animals
KW - Biological Transport
KW - Cell Cycle
KW - Cell Division
KW - Cell Membrane
KW - Clathrin
KW - Endocytosis
KW - Humans
KW - Mice
KW - Microtubules
KW - Mitosis
KW - Phosphorylation
KW - Spindle Apparatus
KW - Transferrin
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1007/s00018-012-1250-8
DO - 10.1007/s00018-012-1250-8
M3 - Journal article
C2 - 23307073
VL - 70
SP - 3423
EP - 3433
JO - Cellular and Molecular Life Sciences : CMLS
JF - Cellular and Molecular Life Sciences : CMLS
SN - 1420-682X
IS - 18
ER -