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Multi-scale interaction of particulate flow and the artery wall

Research output: Contribution to journalJournal article

Published
  • I. Halliday
  • M. Atherton
  • C. M. Care
  • M. W. Collins
  • David Evans
  • P. C. Evans
  • D. R. Hose
  • A. W. Khir
  • C. S. Konig
  • R. Krams
  • P. V. Lawford
  • S. V. Lishchuk
  • G. Pontrelli
  • V. Ridger
  • T. J. Spencer
  • Y. Ventikos
  • D. C. Walker
  • P. N. Watton
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<mark>Journal publication date</mark>09/2011
<mark>Journal</mark>Medical Engineering and Physics
Issue number7
Volume33
Number of pages9
Pages (from-to)840-848
Publication StatusPublished
Early online date29/10/10
<mark>Original language</mark>English

Abstract

We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.