Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Multi-scale interaction of particulate flow and the artery wall
AU - Halliday, I.
AU - Atherton, M.
AU - Care, C. M.
AU - Collins, M. W.
AU - Evans, David
AU - Evans, P. C.
AU - Hose, D. R.
AU - Khir, A. W.
AU - Konig, C. S.
AU - Krams, R.
AU - Lawford, P. V.
AU - Lishchuk, S. V.
AU - Pontrelli, G.
AU - Ridger, V.
AU - Spencer, T. J.
AU - Ventikos, Y.
AU - Walker, D. C.
AU - Watton, P. N.
PY - 2011/9
Y1 - 2011/9
N2 - We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.
AB - We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.
KW - Multi-scale
KW - Microcirculation
KW - Endothelium
KW - Wall shear stress
KW - Glycocalyx
U2 - 10.1016/j.medengphy.2010.09.007
DO - 10.1016/j.medengphy.2010.09.007
M3 - Journal article
VL - 33
SP - 840
EP - 848
JO - Medical Engineering and Physics
JF - Medical Engineering and Physics
SN - 1350-4533
IS - 7
ER -