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Noise in interacting biological systems

Research output: Contribution to conference - Without ISBN/ISSN Conference paper

Published
Publication date23/08/2019
Original languageEnglish
Event25th International Conference on Noise and Fluctuations - EPFL, Neuchâtel, Switzerland
Duration: 18/06/201921/06/2019

Conference

Conference25th International Conference on Noise and Fluctuations
Abbreviated titleICNF 2019
CountrySwitzerland
CityNeuchâtel
Period18/06/1921/06/19

Abstract

Biological systems are never isolated, usually oscillatory, and invariably subject to noise and fluctuations that may be of either internal or external origin. We present a methodological framework for studying the deterministic interactions of biological oscillatory systems, while at the same time decomposing and evaluating the noise strength. Based on dynamical Bayesian inference, the method models coupled phase oscillators in the presence of dynamical noise. We demonstrate first the potential and the precision of the method on a predefined numerical system. Then we illustrate its usefulness in detecting how the noise
strengths from three human physiological systems – the heart, the lungs and the brain – are affected by general anæsthesia. The results demonstrate the potential of the method for detecting and quantifying noise from biological dynamical systems, quite generally.