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Organic electronic materials for gene delivery

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

Publication date13/01/2016
Host publicationEngineering of nanobiomaterials: Applications of nanobiomaterials
EditorsAlexandru Grumezescu
Number of pages26
ISBN (Electronic)9780323417341
Original languageEnglish


Gene therapy has the potential to treat various diseases by altering levels of protein expression, or correcting genetic mutations. A prerequisite of effective gene is the delivery of polynucleic acids (e.g., DNA, RNA) to a patient’s cells which can be achieved by a variety of means, including technological (e.g., electroporation), viruses (which are nature’s gene delivery vectors) or non-viral vectors (e.g., lipids, nanoparticles, polymers). The focus of this chapter is the use of organic electronic materials (i.e., fullerenes, graphenes and conjugated polymers) as non-viral gene delivery vectors and their potential for application as novel theranostic devices. These represent an exciting new class of non-viral vectors that are at the frontier of novel approaches towards gene therapy.