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Oscillatory dynamics of vasoconstriction and vasodilation identified by time-localized phase coherence

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Oscillatory dynamics of vasoconstriction and vasodilation identified by time-localized phase coherence. / Sheppard, Lawrence W.; Vuksanovic, V.; McClintock, P. V. E. et al.
In: Physics in Medicine and Biology, Vol. 56, No. 12, 21.06.2011, p. 3583-3601.

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Sheppard LW, Vuksanovic V, McClintock PVE, Stefanovska A. Oscillatory dynamics of vasoconstriction and vasodilation identified by time-localized phase coherence. Physics in Medicine and Biology. 2011 Jun 21;56(12):3583-3601. doi: 10.1088/0031-9155/56/12/009

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Sheppard, Lawrence W. ; Vuksanovic, V. ; McClintock, P. V. E. et al. / Oscillatory dynamics of vasoconstriction and vasodilation identified by time-localized phase coherence. In: Physics in Medicine and Biology. 2011 ; Vol. 56, No. 12. pp. 3583-3601.

Bibtex

@article{36264bfee8ae4d208af051f7a9a271a0,
title = "Oscillatory dynamics of vasoconstriction and vasodilation identified by time-localized phase coherence",
abstract = "We apply wavelet-based time-localized phase coherence to investigate the relationship between blood flow and skin temperature, and between blood flow and instantaneous heart rate (IHR), during vasoconstriction and vasodilation provoked by local cooling or heating of the skin. A temperature-controlled metal plate (approximate to 10 cm(2)) placed on the volar side of the left arm was used to provide the heating and cooling. Beneath the plate, the blood flow was measured by laser Doppler flowmetry and the adjacent skin temperature by a thermistor. Two 1 h datasets were collected from each of the ten subjects. In each case a 30 min basal recording was followed by a step change in plate temperature, to either 24 degrees C or 42 degrees C. The IHR was derived from simultaneously recorded ECG. We confirm the changes in the energy and frequency of blood flow oscillations during cooling and heating reported earlier. That is, during cooling, there was a significant decrease in the average frequency of myogenic blood flow oscillations (p < 0.05) and the myogenic spectral peak became more prominent. During heating, there was a significant (p < 0.05) general increase in spectral energy, associated with vasodilation, except in the myogenic interval. Weak phase coherence between temperature and blood flow was observed for unperturbed skin, but it increased in all frequency intervals as a result of heating. It was not significantly affected by cooling. We also show that significant (p < 0.05) phase coherence exists between blood flow and IHR in the respiratory and myogenic frequency intervals. Cooling did not affect this phase coherence in any of the frequency intervals, whereas heating enhanced the phase coherence in the respiratory and myogenic intervals. This can be explained by the reduction in vascular resistance produced by heating, a process where myogenic mechanisms play a key role. We conclude that the mechanisms of vasodilation and vasoconstriction, in response to temperature change, are oscillatory in nature and are independent of central sources of variability.",
keywords = "SKIN BLOOD-FLOW, LASER-DOPPLER FLOWMETRY, HEART-RATE-VARIABILITY, NITRIC-OXIDE, WAVELET ANALYSIS, CUTANEOUS VASOCONSTRICTION, CONTROL-SYSTEM, IN-VIVO, TEMPERATURE, HUMANS",
author = "Sheppard, {Lawrence W.} and V. Vuksanovic and McClintock, {P. V. E.} and A. Stefanovska",
year = "2011",
month = jun,
day = "21",
doi = "10.1088/0031-9155/56/12/009",
language = "English",
volume = "56",
pages = "3583--3601",
journal = "Physics in Medicine and Biology",
issn = "1361-6560",
publisher = "IOP Publishing Ltd.",
number = "12",

}

RIS

TY - JOUR

T1 - Oscillatory dynamics of vasoconstriction and vasodilation identified by time-localized phase coherence

AU - Sheppard, Lawrence W.

AU - Vuksanovic, V.

AU - McClintock, P. V. E.

AU - Stefanovska, A.

PY - 2011/6/21

Y1 - 2011/6/21

N2 - We apply wavelet-based time-localized phase coherence to investigate the relationship between blood flow and skin temperature, and between blood flow and instantaneous heart rate (IHR), during vasoconstriction and vasodilation provoked by local cooling or heating of the skin. A temperature-controlled metal plate (approximate to 10 cm(2)) placed on the volar side of the left arm was used to provide the heating and cooling. Beneath the plate, the blood flow was measured by laser Doppler flowmetry and the adjacent skin temperature by a thermistor. Two 1 h datasets were collected from each of the ten subjects. In each case a 30 min basal recording was followed by a step change in plate temperature, to either 24 degrees C or 42 degrees C. The IHR was derived from simultaneously recorded ECG. We confirm the changes in the energy and frequency of blood flow oscillations during cooling and heating reported earlier. That is, during cooling, there was a significant decrease in the average frequency of myogenic blood flow oscillations (p < 0.05) and the myogenic spectral peak became more prominent. During heating, there was a significant (p < 0.05) general increase in spectral energy, associated with vasodilation, except in the myogenic interval. Weak phase coherence between temperature and blood flow was observed for unperturbed skin, but it increased in all frequency intervals as a result of heating. It was not significantly affected by cooling. We also show that significant (p < 0.05) phase coherence exists between blood flow and IHR in the respiratory and myogenic frequency intervals. Cooling did not affect this phase coherence in any of the frequency intervals, whereas heating enhanced the phase coherence in the respiratory and myogenic intervals. This can be explained by the reduction in vascular resistance produced by heating, a process where myogenic mechanisms play a key role. We conclude that the mechanisms of vasodilation and vasoconstriction, in response to temperature change, are oscillatory in nature and are independent of central sources of variability.

AB - We apply wavelet-based time-localized phase coherence to investigate the relationship between blood flow and skin temperature, and between blood flow and instantaneous heart rate (IHR), during vasoconstriction and vasodilation provoked by local cooling or heating of the skin. A temperature-controlled metal plate (approximate to 10 cm(2)) placed on the volar side of the left arm was used to provide the heating and cooling. Beneath the plate, the blood flow was measured by laser Doppler flowmetry and the adjacent skin temperature by a thermistor. Two 1 h datasets were collected from each of the ten subjects. In each case a 30 min basal recording was followed by a step change in plate temperature, to either 24 degrees C or 42 degrees C. The IHR was derived from simultaneously recorded ECG. We confirm the changes in the energy and frequency of blood flow oscillations during cooling and heating reported earlier. That is, during cooling, there was a significant decrease in the average frequency of myogenic blood flow oscillations (p < 0.05) and the myogenic spectral peak became more prominent. During heating, there was a significant (p < 0.05) general increase in spectral energy, associated with vasodilation, except in the myogenic interval. Weak phase coherence between temperature and blood flow was observed for unperturbed skin, but it increased in all frequency intervals as a result of heating. It was not significantly affected by cooling. We also show that significant (p < 0.05) phase coherence exists between blood flow and IHR in the respiratory and myogenic frequency intervals. Cooling did not affect this phase coherence in any of the frequency intervals, whereas heating enhanced the phase coherence in the respiratory and myogenic intervals. This can be explained by the reduction in vascular resistance produced by heating, a process where myogenic mechanisms play a key role. We conclude that the mechanisms of vasodilation and vasoconstriction, in response to temperature change, are oscillatory in nature and are independent of central sources of variability.

KW - SKIN BLOOD-FLOW

KW - LASER-DOPPLER FLOWMETRY

KW - HEART-RATE-VARIABILITY

KW - NITRIC-OXIDE

KW - WAVELET ANALYSIS

KW - CUTANEOUS VASOCONSTRICTION

KW - CONTROL-SYSTEM

KW - IN-VIVO

KW - TEMPERATURE

KW - HUMANS

U2 - 10.1088/0031-9155/56/12/009

DO - 10.1088/0031-9155/56/12/009

M3 - Journal article

VL - 56

SP - 3583

EP - 3601

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 1361-6560

IS - 12

ER -