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  • CARBPOL-D-18-02824R2

    Rights statement: This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 205, 2019 DOI: 10.1016/j.carbpol.2018.10.061

    Accepted author manuscript, 1.69 MB, PDF document

    Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

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Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity

Research output: Contribution to journalJournal articlepeer-review

Published
  • Timothy Edward Lim Douglas
  • Michal Dziadek
  • Josefien Schietse
  • Matthieu Boone
  • Heidi Declercq
  • Tom Coenye
  • Valerie Vanhoorne
  • Chris Vervaet
  • Lieve Balcaen
  • Maria Buchweitz
  • Frank Vanhaecke
  • Frederic Van Assche
  • Katarzyna Cholewa-Kowalska
  • Andre G. Skirtach
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<mark>Journal publication date</mark>1/02/2019
<mark>Journal</mark>Carbohydrate Polymers
Volume205
Number of pages10
Pages (from-to)427-436
Publication StatusPublished
Early online date26/10/18
<mark>Original language</mark>English

Abstract

The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gelderived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20% w/v BG particles of two different sizes (2.5 and <45 µm). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. µCT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 205, 2019 DOI: 10.1016/j.carbpol.2018.10.061