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  • CARBPOL-D-18-02824R2

    Rights statement: This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 205, 2019 DOI: 10.1016/j.carbpol.2018.10.061

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Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity

Research output: Contribution to journalJournal articlepeer-review

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Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity. / Douglas, Timothy Edward Lim; Dziadek, Michal; Schietse, Josefien; Boone, Matthieu; Declercq, Heidi; Coenye, Tom; Vanhoorne, Valerie; Vervaet, Chris; Balcaen, Lieve; Buchweitz, Maria; Vanhaecke, Frank; Van Assche, Frederic; Cholewa-Kowalska, Katarzyna; Skirtach, Andre G.

In: Carbohydrate Polymers, Vol. 205, 01.02.2019, p. 427-436.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Douglas, TEL, Dziadek, M, Schietse, J, Boone, M, Declercq, H, Coenye, T, Vanhoorne, V, Vervaet, C, Balcaen, L, Buchweitz, M, Vanhaecke, F, Van Assche, F, Cholewa-Kowalska, K & Skirtach, AG 2019, 'Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity', Carbohydrate Polymers, vol. 205, pp. 427-436. https://doi.org/10.1016/j.carbpol.2018.10.061

APA

Douglas, T. E. L., Dziadek, M., Schietse, J., Boone, M., Declercq, H., Coenye, T., Vanhoorne, V., Vervaet, C., Balcaen, L., Buchweitz, M., Vanhaecke, F., Van Assche, F., Cholewa-Kowalska, K., & Skirtach, A. G. (2019). Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity. Carbohydrate Polymers, 205, 427-436. https://doi.org/10.1016/j.carbpol.2018.10.061

Vancouver

Author

Douglas, Timothy Edward Lim ; Dziadek, Michal ; Schietse, Josefien ; Boone, Matthieu ; Declercq, Heidi ; Coenye, Tom ; Vanhoorne, Valerie ; Vervaet, Chris ; Balcaen, Lieve ; Buchweitz, Maria ; Vanhaecke, Frank ; Van Assche, Frederic ; Cholewa-Kowalska, Katarzyna ; Skirtach, Andre G. / Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity. In: Carbohydrate Polymers. 2019 ; Vol. 205. pp. 427-436.

Bibtex

@article{157f4b6b1fcb4517847bfbb28f90f43b,
title = "Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity",
abstract = "The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gelderived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20% w/v BG particles of two different sizes (2.5 and <45 µm). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. µCT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.",
keywords = "Antibacterial, Bioactive glass, Bone tissue engineering, Hydrogel, Pectin, Bacteria, Gelation, Hydrogels, Sol-gels, Tissue engineering, Anti-bacterial activity, Inhomogeneous distribution, Methicilin resistant staphylococcus aureus, Mineralization process, Simulated body fluids",
author = "Douglas, {Timothy Edward Lim} and Michal Dziadek and Josefien Schietse and Matthieu Boone and Heidi Declercq and Tom Coenye and Valerie Vanhoorne and Chris Vervaet and Lieve Balcaen and Maria Buchweitz and Frank Vanhaecke and {Van Assche}, Frederic and Katarzyna Cholewa-Kowalska and Skirtach, {Andre G.}",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 205, 2019 DOI: 10.1016/j.carbpol.2018.10.061",
year = "2019",
month = feb,
day = "1",
doi = "10.1016/j.carbpol.2018.10.061",
language = "English",
volume = "205",
pages = "427--436",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity

AU - Douglas, Timothy Edward Lim

AU - Dziadek, Michal

AU - Schietse, Josefien

AU - Boone, Matthieu

AU - Declercq, Heidi

AU - Coenye, Tom

AU - Vanhoorne, Valerie

AU - Vervaet, Chris

AU - Balcaen, Lieve

AU - Buchweitz, Maria

AU - Vanhaecke, Frank

AU - Van Assche, Frederic

AU - Cholewa-Kowalska, Katarzyna

AU - Skirtach, Andre G.

N1 - This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 205, 2019 DOI: 10.1016/j.carbpol.2018.10.061

PY - 2019/2/1

Y1 - 2019/2/1

N2 - The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gelderived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20% w/v BG particles of two different sizes (2.5 and <45 µm). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. µCT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.

AB - The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gelderived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20% w/v BG particles of two different sizes (2.5 and <45 µm). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. µCT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.

KW - Antibacterial

KW - Bioactive glass

KW - Bone tissue engineering

KW - Hydrogel

KW - Pectin

KW - Bacteria

KW - Gelation

KW - Hydrogels

KW - Sol-gels

KW - Tissue engineering

KW - Anti-bacterial activity

KW - Inhomogeneous distribution

KW - Methicilin resistant staphylococcus aureus

KW - Mineralization process

KW - Simulated body fluids

U2 - 10.1016/j.carbpol.2018.10.061

DO - 10.1016/j.carbpol.2018.10.061

M3 - Journal article

VL - 205

SP - 427

EP - 436

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

ER -