Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Photochemical activity of membrane-localised polyketide derived marine natural products
AU - Powell, Kimberley J.
AU - Richens, Joanna L.
AU - Bramble, Jonathan P.
AU - Han, Li Chen
AU - Sharma, Pallavi
AU - O'Shea, Paul
AU - Moses, John E.
PY - 2018/3/22
Y1 - 2018/3/22
N2 - Marine organisms rely upon complex bio-chemical systems to manage photo-induced oxidative damage as part of a sophisticated chemical defense. Using a combination of synthetic chemistry and biophysical techniques, we provide evidence to support the notion that marine derived polyene γ-pyrone metabolites of sacoglossan molluscs become localised at cell membranes where they influence the total absorption of the harmful radiation by the lipid membrane, thereby functioning as sunscreen agents. We also report two new hyperperoxide analogues of the putative polyene biosynthetic precursors that themselves are likely candidate natural products.
AB - Marine organisms rely upon complex bio-chemical systems to manage photo-induced oxidative damage as part of a sophisticated chemical defense. Using a combination of synthetic chemistry and biophysical techniques, we provide evidence to support the notion that marine derived polyene γ-pyrone metabolites of sacoglossan molluscs become localised at cell membranes where they influence the total absorption of the harmful radiation by the lipid membrane, thereby functioning as sunscreen agents. We also report two new hyperperoxide analogues of the putative polyene biosynthetic precursors that themselves are likely candidate natural products.
KW - Membrane-localised
KW - Polyketide
KW - Sunscreen
KW - Tridachiahydropyrone
KW - γ-Pyrone natural products
U2 - 10.1016/j.tet.2017.10.056
DO - 10.1016/j.tet.2017.10.056
M3 - Journal article
VL - 74
SP - 1191
EP - 1198
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 12
ER -