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Photochemical activity of membrane-localised polyketide derived marine natural products

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Photochemical activity of membrane-localised polyketide derived marine natural products. / Powell, Kimberley J.; Richens, Joanna L.; Bramble, Jonathan P. et al.
In: Tetrahedron, Vol. 74, No. 12, 22.03.2018, p. 1191-1198.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Powell, KJ, Richens, JL, Bramble, JP, Han, LC, Sharma, P, O'Shea, P & Moses, JE 2018, 'Photochemical activity of membrane-localised polyketide derived marine natural products', Tetrahedron, vol. 74, no. 12, pp. 1191-1198. https://doi.org/10.1016/j.tet.2017.10.056

APA

Powell, K. J., Richens, J. L., Bramble, J. P., Han, L. C., Sharma, P., O'Shea, P., & Moses, J. E. (2018). Photochemical activity of membrane-localised polyketide derived marine natural products. Tetrahedron, 74(12), 1191-1198. https://doi.org/10.1016/j.tet.2017.10.056

Vancouver

Powell KJ, Richens JL, Bramble JP, Han LC, Sharma P, O'Shea P et al. Photochemical activity of membrane-localised polyketide derived marine natural products. Tetrahedron. 2018 Mar 22;74(12):1191-1198. Epub 2017 Oct 23. doi: 10.1016/j.tet.2017.10.056

Author

Powell, Kimberley J. ; Richens, Joanna L. ; Bramble, Jonathan P. et al. / Photochemical activity of membrane-localised polyketide derived marine natural products. In: Tetrahedron. 2018 ; Vol. 74, No. 12. pp. 1191-1198.

Bibtex

@article{dbac7341d89d49218ba805872906e5b2,
title = "Photochemical activity of membrane-localised polyketide derived marine natural products",
abstract = "Marine organisms rely upon complex bio-chemical systems to manage photo-induced oxidative damage as part of a sophisticated chemical defense. Using a combination of synthetic chemistry and biophysical techniques, we provide evidence to support the notion that marine derived polyene γ-pyrone metabolites of sacoglossan molluscs become localised at cell membranes where they influence the total absorption of the harmful radiation by the lipid membrane, thereby functioning as sunscreen agents. We also report two new hyperperoxide analogues of the putative polyene biosynthetic precursors that themselves are likely candidate natural products.",
keywords = "Membrane-localised, Polyketide, Sunscreen, Tridachiahydropyrone, γ-Pyrone natural products",
author = "Powell, {Kimberley J.} and Richens, {Joanna L.} and Bramble, {Jonathan P.} and Han, {Li Chen} and Pallavi Sharma and Paul O'Shea and Moses, {John E.}",
year = "2018",
month = mar,
day = "22",
doi = "10.1016/j.tet.2017.10.056",
language = "English",
volume = "74",
pages = "1191--1198",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "12",

}

RIS

TY - JOUR

T1 - Photochemical activity of membrane-localised polyketide derived marine natural products

AU - Powell, Kimberley J.

AU - Richens, Joanna L.

AU - Bramble, Jonathan P.

AU - Han, Li Chen

AU - Sharma, Pallavi

AU - O'Shea, Paul

AU - Moses, John E.

PY - 2018/3/22

Y1 - 2018/3/22

N2 - Marine organisms rely upon complex bio-chemical systems to manage photo-induced oxidative damage as part of a sophisticated chemical defense. Using a combination of synthetic chemistry and biophysical techniques, we provide evidence to support the notion that marine derived polyene γ-pyrone metabolites of sacoglossan molluscs become localised at cell membranes where they influence the total absorption of the harmful radiation by the lipid membrane, thereby functioning as sunscreen agents. We also report two new hyperperoxide analogues of the putative polyene biosynthetic precursors that themselves are likely candidate natural products.

AB - Marine organisms rely upon complex bio-chemical systems to manage photo-induced oxidative damage as part of a sophisticated chemical defense. Using a combination of synthetic chemistry and biophysical techniques, we provide evidence to support the notion that marine derived polyene γ-pyrone metabolites of sacoglossan molluscs become localised at cell membranes where they influence the total absorption of the harmful radiation by the lipid membrane, thereby functioning as sunscreen agents. We also report two new hyperperoxide analogues of the putative polyene biosynthetic precursors that themselves are likely candidate natural products.

KW - Membrane-localised

KW - Polyketide

KW - Sunscreen

KW - Tridachiahydropyrone

KW - γ-Pyrone natural products

U2 - 10.1016/j.tet.2017.10.056

DO - 10.1016/j.tet.2017.10.056

M3 - Journal article

VL - 74

SP - 1191

EP - 1198

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 12

ER -