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Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease

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Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. / Hamilton, Gillian; Samedi, Farzana; Knight, Jo; Archer, Nicola; Foy, Catherine; Walter, Sarah; Turic, Dragana; Jehu, Luke; Moore, Pamela; Hollingworth, Paul; O'Donovan, Michael C.; Williams, Julie; Owen, Michael J.; Lovestone, Simon; Powell, John F.

In: Neuroscience Letters, Vol. 401, No. 1-2, 19.06.2006, p. 77-80.

Research output: Contribution to journalJournal article

Harvard

Hamilton, G, Samedi, F, Knight, J, Archer, N, Foy, C, Walter, S, Turic, D, Jehu, L, Moore, P, Hollingworth, P, O'Donovan, MC, Williams, J, Owen, MJ, Lovestone, S & Powell, JF 2006, 'Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease', Neuroscience Letters, vol. 401, no. 1-2, pp. 77-80. https://doi.org/10.1016/j.neulet.2006.03.021

APA

Hamilton, G., Samedi, F., Knight, J., Archer, N., Foy, C., Walter, S., Turic, D., Jehu, L., Moore, P., Hollingworth, P., O'Donovan, M. C., Williams, J., Owen, M. J., Lovestone, S., & Powell, J. F. (2006). Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Neuroscience Letters, 401(1-2), 77-80. https://doi.org/10.1016/j.neulet.2006.03.021

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Author

Hamilton, Gillian ; Samedi, Farzana ; Knight, Jo ; Archer, Nicola ; Foy, Catherine ; Walter, Sarah ; Turic, Dragana ; Jehu, Luke ; Moore, Pamela ; Hollingworth, Paul ; O'Donovan, Michael C. ; Williams, Julie ; Owen, Michael J. ; Lovestone, Simon ; Powell, John F. / Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. In: Neuroscience Letters. 2006 ; Vol. 401, No. 1-2. pp. 77-80.

Bibtex

@article{a2d99c2a198e4f6aa40484bd88b45974,
title = "Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease",
abstract = "The varepsilon4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.",
keywords = "Aged, Aged, 80 and over, Alzheimer Disease, Brain, Brain Chemistry, DNA Mutational Analysis, Female, Gene Frequency, Genetic Markers, Genetic Predisposition to Disease, Genetic Testing, Humans, Linkage Disequilibrium, Male, Mutation, PTEN Phosphohydrolase, Polymorphism, Genetic, Polymorphism, Single Nucleotide",
author = "Gillian Hamilton and Farzana Samedi and Jo Knight and Nicola Archer and Catherine Foy and Sarah Walter and Dragana Turic and Luke Jehu and Pamela Moore and Paul Hollingworth and O'Donovan, {Michael C.} and Julie Williams and Owen, {Michael J.} and Simon Lovestone and Powell, {John F.}",
year = "2006",
month = jun,
day = "19",
doi = "10.1016/j.neulet.2006.03.021",
language = "English",
volume = "401",
pages = "77--80",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "ELSEVIER IRELAND LTD",
number = "1-2",

}

RIS

TY - JOUR

T1 - Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease

AU - Hamilton, Gillian

AU - Samedi, Farzana

AU - Knight, Jo

AU - Archer, Nicola

AU - Foy, Catherine

AU - Walter, Sarah

AU - Turic, Dragana

AU - Jehu, Luke

AU - Moore, Pamela

AU - Hollingworth, Paul

AU - O'Donovan, Michael C.

AU - Williams, Julie

AU - Owen, Michael J.

AU - Lovestone, Simon

AU - Powell, John F.

PY - 2006/6/19

Y1 - 2006/6/19

N2 - The varepsilon4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.

AB - The varepsilon4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Brain

KW - Brain Chemistry

KW - DNA Mutational Analysis

KW - Female

KW - Gene Frequency

KW - Genetic Markers

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Mutation

KW - PTEN Phosphohydrolase

KW - Polymorphism, Genetic

KW - Polymorphism, Single Nucleotide

U2 - 10.1016/j.neulet.2006.03.021

DO - 10.1016/j.neulet.2006.03.021

M3 - Journal article

C2 - 16574322

VL - 401

SP - 77

EP - 80

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -