Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease
AU - Hamilton, Gillian
AU - Samedi, Farzana
AU - Knight, Jo
AU - Archer, Nicola
AU - Foy, Catherine
AU - Walter, Sarah
AU - Turic, Dragana
AU - Jehu, Luke
AU - Moore, Pamela
AU - Hollingworth, Paul
AU - O'Donovan, Michael C.
AU - Williams, Julie
AU - Owen, Michael J.
AU - Lovestone, Simon
AU - Powell, John F.
PY - 2006/6/19
Y1 - 2006/6/19
N2 - The varepsilon4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.
AB - The varepsilon4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.
KW - Aged
KW - Aged, 80 and over
KW - Alzheimer Disease
KW - Brain
KW - Brain Chemistry
KW - DNA Mutational Analysis
KW - Female
KW - Gene Frequency
KW - Genetic Markers
KW - Genetic Predisposition to Disease
KW - Genetic Testing
KW - Humans
KW - Linkage Disequilibrium
KW - Male
KW - Mutation
KW - PTEN Phosphohydrolase
KW - Polymorphism, Genetic
KW - Polymorphism, Single Nucleotide
U2 - 10.1016/j.neulet.2006.03.021
DO - 10.1016/j.neulet.2006.03.021
M3 - Journal article
C2 - 16574322
VL - 401
SP - 77
EP - 80
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -