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    Rights statement: This is the author’s version of a work that was accepted for publication in Chemical Data Collections. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Data Collections, 9-10, 2017 DOI: 10.1016/j.cdc.2016.11.007

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Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives

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<mark>Journal publication date</mark>08/2017
<mark>Journal</mark>Chemical Data Collections
Volume9-10
Number of pages14
Pages (from-to)263-276
<mark>State</mark>Published
Early online date29/11/16
<mark>Original language</mark>English

Abstract

Abstract In the present study, three biologically active, substituted acyl thiourea compounds (1–3) have been synthesized from 2,4-dichlorobenzoyl chloride, potassium thiocyanate and the corresponding secondary amine in dry acetone. As analytical and spectral data of 1 and 3 have already been discussed in the literature, only the compound 2 was characterized by elemental analyses, UV–Visible, FT–IR, 1H & 13C NMR spectroscopic techniques. The molecular structures of 1–3 were determined by single crystal X-ray crystallography which shows twists of up to 70° about the (S=)C–NC(=O) bonds. All the synthesized compounds show good antioxidant property and cytotoxic potential against Ehrlich Ascites Carcinoma (EAC) cancer cell line.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Chemical Data Collections. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Data Collections, 9-10, 2017 DOI: 10.1016/j.cdc.2016.11.007