Electronic data
- Manuscript_JBMR_symplectic
Rights statement: This is the peer reviewed version of the following article: Lane, J.C., Butler, K.L., Poveda‐Marina, J.L., Martinez‐Laguna, D., Reyes, C., de Bont, J., Javaid, M.K., Logue, J., Compston, J.E., Cooper, C., Duarte‐Salles, T., Furniss, D. and Prieto‐Alhambra, D. (2020), Preschool Obesity Is Associated With an Increased Risk of Childhood Fracture: A Longitudinal Cohort Study of 466,997 Children and Up to 11 Years of Follow‐up in Catalonia, Spain. J Bone Miner Res. doi:10.1002/jbmr.3984 which has been published in final form at https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.3984 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Accepted author manuscript, 505 KB, PDF document
Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License
Links
- https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.3984
Final published version
Text available via DOI:
Pre-school obesity is associated with an increased risk of childhood fracture: a longitudinal cohort study of 466 997 children and up to 11 years of follow up in Catalonia, Spain
Research output: Contribution to Journal/Magazine › Journal article › peer-review
| <mark>Journal publication date</mark> | 1/06/2020 |
|---|---|
| <mark>Journal</mark> | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research |
| Issue number | 6 |
| Volume | 35 |
| Number of pages | 9 |
| Pages (from-to) | 1022-1030 |
| Publication Status | Published |
| Early online date | 7/04/20 |
| <mark>Original language</mark> | English |
Abstract
This study aimed to determine if having an overweight or obese range body mass index (BMI) at time of beginning school is associated with increased fracture incidence in childhood. A dynamic cohort was created from children presenting for routine preschool primary care screening, collected in the Information System for Research in Primary Care (SIDIAP) platform in Catalonia, Spain. Data were collected from 296 primary care centers representing 74% of the regional pediatric population. A total of 466,997 children (48.6% female) with a validated weight and height measurement within routine health care screening at age 4 years (±6 months) between 2006 and 2013 were included, and followed up to the age of 15, migration out of region, death, or until December 31, 2016. BMI was calculated at age 4 years and classified using WHO growth tables, and fractures were identified using previously validated ICD10 codes in electronic primary care records, divided by anatomical location. Actuarial lifetables were used to calculate cumulative incidence. Cox regression was used to investigate the association of BMI category and fracture risk with adjustment for socioeconomic status, age, sex, and nationality. Median follow-up was 4.90 years (interquartile range [IQR] 2.50 to 7.61). Cumulative incidence of any fracture during childhood was 9.20% (95% confidence interval [CI] 3.79% to 14.61%) for underweight, 10.06% (9.82% to 10.29%) for normal weight, 11.28% (10.22% to 12.35%) for overweight children, and 13.05% (10.69% to 15.41%) for children with obesity. Compared with children of normal range weight, having an overweight and obese range BMI was associated with an excess risk of lower limb fracture (adjusted hazard ratio [HR] = 1.42 [1.26 to 1.59]; 1.74 [1.46 to 2.06], respectively) and upper limb fracture (adjusted HR = 1.10 [1.03 to 1.17]; 1.19 [1.07 to 1.31]). Overall, preschool children with an overweight or obese range BMI had increased incidence of upper and lower limb fractures in childhood compared with contemporaries of normal weight.