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Race-specific differences in the phase coherence between blood flow and oxygenation: A simultaneous NIRS, white light spectroscopy and LDF study

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E-pub ahead of print
Article numbere201960131
<mark>Journal publication date</mark>3/02/2020
<mark>Journal</mark>Journal of Biophotonics
Number of pages15
Publication statusE-pub ahead of print
Early online date3/02/20
Original languageEnglish

Abstract

Race-specific differences in the level of glycated haemoglobin are well known. How-ever, these differences were detected by invasive measurement of mean oxygenation, and their understanding remains far from complete. Given that oxygen is delivered to the cells by haemoglobin through the cardiovascular system, a possible approach is to investigate the phase coherence between blood flow and oxygen transportation. Here we introduce a non-invasive optical method based on simultaneous recordings using NIRS, white light spectroscopy and LDF, combined with wavelet-based phase coherence analysis. Signals were recorded simultaneously for individuals in two groups of healthy subjects, 16 from Sub-Saharan Africa (BA group) and 16 Europeans (CA group). It was found that the power of myogenic oscillations in oxygenated and de-oxygenated haemoglobin is higher in the BA group, but that the phase coherence between blood flow and oxygen saturation, or blood flow and haemoglobin concentrations is higher in the CA group.