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Rapid Evolution and the Importance of Recombination to the Gastroenteric Pathogen Campylobacter jejuni

Research output: Contribution to journalJournal article

Published

  • Daniel J. Wilson
  • Edith Gabriel
  • Andrew J. H. Leatherbarrow
  • John Cheesbrough
  • Steven Gee
  • Eric Bolton
  • Andrew Fox
  • C. Anthony Hart
  • Peter J. Diggle
  • Paul Fearnhead
Journal publication date02/2009
JournalMolecular Biology and Evolution
Journal number2
Volume26
Number of pages13
Pages385-397
Original languageEnglish

Abstract

Responsible for the majority of bacterial gastroenteritis in the developed world, Campylobacter jejuni is a pervasive pathogen of humans and animals, but its evolution is obscure. In this paper, we exploit contemporary genetic diversity and empirical evidence to piece together the evolutionary history of C. jejuni and quantify its evolutionary potential. Our combined population genetics-phylogenetics approach reveals a surprising picture. Campylobacter jejuni is a rapidly evolving species, subject to intense purifying selection that purges 60% of novel variation, but possessing a massive evolutionary potential. The low mutation rate is offset by a large effective population size so that a mutation at any site can occur somewhere in the population within the space of a week. Recombination has a fundamental role, generating diversity at twice the rate of de novo mutation, and facilitating gene flow between C. jejuni and its sister species Campylobacter coli. We attempt to calibrate the rate of molecular evolution in C. jejuni based solely on within-species variation. The rates we obtain are up to 1,000 times faster than conventional estimates, placing the C. jejuni-C. coli split at the time of the Neolithic revolution. We weigh the plausibility of such recent bacterial evolution against alternative explanations and discuss the evidence required to settle the issue.

Bibliographic note

© 2008 The Authors This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.