Rights statement: This article has been accepted for publication in BMJ Supportive & Palliative Care, 2020 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/bmjspcare-2019-002051 © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) http://creativecommons.org BMJ Authors Self-Archiving Policy, September 2018 https://creativecommons.org/licenses/by-nc/4.0/
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Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Refractory pruritus from malignant cholestasis
T2 - Management
AU - Gunasekara Vidana Mestrige Fernando, Chamath
AU - Preston, Nancy
N1 - This article has been accepted for publication in BMJ Supportive & Palliative Care, 2020 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/bmjspcare-2019-002051 © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) http://creativecommons.org BMJ Authors Self-Archiving Policy, September 2018 https://creativecommons.org/licenses/by-nc/4.0/
PY - 2023/10/31
Y1 - 2023/10/31
N2 - This case report deals with a patient managed in a tertiary-care cancer hospital who suffered pruritus associated with malignant cholestasis. His symptoms were resistant to conventional treatment with ursodeoxycholic acid, chlorpheniramine and cholestyramine. Hence, the multifactorial origin of malignancy-associated pruritus was considered. Correctable factors were corrected and generally the treatment was aimed at possible aetiologies. There were barriers related to insufficient resources available for symptom palliation in this particular setting, which could potentially reduce optimum symptom control. However, various pharmacotherapies and non-pharmacological measures which could potentially have helped relieve pruritus are described and future scope for research in this area discussed.
AB - This case report deals with a patient managed in a tertiary-care cancer hospital who suffered pruritus associated with malignant cholestasis. His symptoms were resistant to conventional treatment with ursodeoxycholic acid, chlorpheniramine and cholestyramine. Hence, the multifactorial origin of malignancy-associated pruritus was considered. Correctable factors were corrected and generally the treatment was aimed at possible aetiologies. There were barriers related to insufficient resources available for symptom palliation in this particular setting, which could potentially reduce optimum symptom control. However, various pharmacotherapies and non-pharmacological measures which could potentially have helped relieve pruritus are described and future scope for research in this area discussed.
KW - cancer
KW - gastrointestinal (upper)
KW - hospital care
KW - jaundice
KW - pruritis
U2 - 10.1136/bmjspcare-2019-002051
DO - 10.1136/bmjspcare-2019-002051
M3 - Journal article
AN - SCOPUS:85077845098
VL - 13
JO - BMJ Supportive and Palliative Care
JF - BMJ Supportive and Palliative Care
SN - 2045-435X
IS - e1
M1 - 002051
ER -